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Four Research Fellows in Biosensors, Biochemistry, Bioelectronics and Bionanotechnology
Fixed Term of 3 years, available from 1 September 2016
The discovery of antibiotics revolutionised our healthcare system, and antibiotics and other antimicrobials have become an integral part of modern healthcare. However, in recent decades, the use of antibiotics has increased massively, which led to an enormous rise in antimicrobial resistance (AMR).
AMR is a significant and growing world-wide challenge. The world is facing an increase in the number and type of bacteria resistant to antibiotics alongside stagnation in the development of new antibiotics or viable alternatives. It is clear that an interdisciplinary approach at a global level is needed to tackle the challenge if we are to save millions of lives being lost as a result of antibiotic-resistant bacteria.
One of the main reasons for the rapid rise in AMR is a lack of instant and accurate diagnostic tools for infectious diseases. This programme, funded by the Medical Research Council UK (MRC), will develop new tools that can be used by doctors to detect the presence of a bacterial or viral infection quickly before antibiotics are prescribed. The test will also be able to tell which bacterial strain has caused the infection, as different strains require different treatments, and whether the particular type is commonly resistant to antibiotics. This will allow for targeted use of antibiotics, reducing the number of prescriptions and increasing efficacy for patients.
The programme involves a highly interdisciplinary team of researchers from the Faculties of Engineering, Biological Sciences, and Medicine and Health – as well as clinical scientists from the Leeds Teaching Hospital.
We are looking for four highly motivated Research Fellows who are keen to get involved in a multidisciplinary project to develop the next generation of diagnostics for the reduction of AMR.
Research Fellow in Electronic Biosensors for Infection Diagnostics will develop impedimetric biosensors assays to distinguish between bacterial and viral infection using host response markers. Also, this post will develop assays on the same impedimetric platform for the detection of C. difficile toxins, as well as direct detection of enzymes relevant to AMR. Read more and apply →
Research Fellow in Electroactive Recognition Elements for Electronic Biosensors will develop novel approaches for next-generation biosensors for the detection of AMR-relevant markers. In particular, novel redox-active capture molecules will be developed for the direct electrochemical detection of analyte on biosensors. Read more and apply →
Research Fellow in Molecular Amplifiers for Electronic Biosensors will develop novel approaches for next-generation biosensors for the detection of AMR-relevant markers. In particular, novel active binding molecules – resembling molecular amplifiers – to be used as capture molecules on biosensors will be developed. Read more and apply →
Research Fellow in Optical Nanobiosensors for Infection Biomarkers will develop rare earth element up-conversion nanoparticles which are functionalised with bioreceptors (antibodies or Affimers). These nanobiosensor suspensions will be used to distinguish between bacterial and viral infection using host response markers and later to detect bacterial exotoxins. Read more and apply →
All posts are University Grade 7 (£31,656 - £37,768 p.a.)
Informal enquiries about the programme may be made to Professor Christoph Wälti, tel +44 (0)113 343 2023, email C.Walti@leeds.ac.uk