Research Assistant in Renal Iron Homeostasis

University of Oxford - Department of Physiology, Anatomy and Genetics

Applications are invited for a Research Assistant to join Dr Samira Lakhal-Littleton’s group, to work on a project to understand renal iron handling. It will build on preliminary work which suggests that renal ferroportin is regulated both by iron and by hepcidin, to formally understand the role of ferraportin in iron re-absorption and to determine whether hepcidin regulates this process. The project will utilise mouse models where the hepcidin/ferroportin axis is disrupted specifically in the kidney. The group will carry out haematological and histological assessment of iron indices, ELISA-based measurements of parameters of renal function and iron quantitation in urine.

The Research Assistant will take responsibility for the day-to-day management of mouse colonies and carry out phenotypic studies, analysing and interpreting results. You will maintain animal records, and prepare routine lab reagents. You will be expected to manage your own research and administrative activities, reporting to Dr Lakhal-Littleton, who will provide guidelines as required. The post requires the coordination of multiple aspects of work to meet deadlines.

You will hold an MSC or equivalent in a relevant area of research, and have experience of animal husbandry, handling and welfare. A Home Office licence is required for this post, and you will have knowledge of HO regulations and procedures. Experience in histology and immunostaining is desirable, as is previous experience in renal research.

You will be based in the Sherrington Building, Parks Road, Oxford OX1 3PT. The position is funded by Kidney Research UK for a fixed-term of up to 3 years, and is expected to start in January 2017.

In addition to salary you will receive a generous annual leave entitlement, excellent development opportunities and a benefits package.

The closing date for applications is 12.00 noon on Friday 28 October 2016. Interviews are expected to be held on Friday 18 November 2016.

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South East England