Postdoctoral Research Scientist in Neuroscience

University of Oxford

Department of Physiology, Anatomy and Genetics, University of Oxford, Le Gros Clark Building, South Parks Road, Oxford

Applications are invited for a Postdoctoral Research Scientist to join Professor Simon Butt’s group, to work on a project focused on investigating the role of GABAergic interneuron subtypes in the neonatal mammalian brain. The project aims to examine how specific interneuron subtypes contribute to early network oscillations using a combined in vivo electrophysiology and 2-photon imaging approach.

The overall objective of the proposed research is to determine the contribution of GABAergic interneurons to early postnatal cortical oscillations in the normal developing brain and conversely test the requirement for such activity by perturbing early interneuron circuits. This line of investigation builds on previous work in the lab that has used developmental genetics in combination with laser scanning photostimulation and whole cell patch clamp electrophysiology to map the afferent and efferent connections of GABAergic interneurons and pyramidal projection neurons through the first three weeks of postnatal life. The next step is to: determine the contribution of GABAergic interneuron subtypes to neonatal oscillations and then establish if and when interneuron function is necessary for normal cognitive development.

You will hold, or be near completion of, a PhD/DPhil or equivalent in a relevant area of research. You must have experience with animal models, specifically rodents; in vivo electrophysiology; optogenetic tools; two-photon imaging in vivo; data analysis; use of coding in MatLab and/or Python. Holding (or the capability of obtaining) a Home Office Licence (B and C) is required for this post.

You will be based in the Department of Physiology, Anatomy and Genetics, Le Gros Clark Building, South Parks Road, Oxford OX1 3QX. This is a fixed-term post, funded by the BBSRC for up to 3 years.

In addition to salary you will receive a generous annual leave entitlement, excellent development opportunities and a benefits package.

The closing date for applications is 12.00 noon on Friday 4 November 2016. Interviews will take place week commencing 21 November 2016.

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