Postdoctoral Research Scientist - Integral Membrane Protein Group

University of Oxford - Nuffield Department of Medicine (NDM), Structural Genomics Consortium

Old Road Campus Research Building, Roosevelt Drive, Headington, Oxford


We are seeking a Postdoctoral Research Scientist with membrane protein structural biology experience, to study the K2P potassium channels. These channels are required for the excitability of nerve cells and are potential targets for migraine, pain and depression. Our TREK-1 and TREK-2 structures suggested mechanisms for mechanosensitivity and inhibition. We now plan to investigate mechanisms of channel regulation, to enable drug design. You would work with the TREKs, other K2Ps and other ion channels. You will be responsible for the biophysical and structural aspects of the project, using synchrotron and xFEL X-ray crystallography, and potentially also electron microscopy. You will be joining Liz Carpenter’s team of ten membrane protein scientists at the SGC and you will work closely with Professor Stephen Tucker (Physics, Oxford) for electrophysiology.

To qualify for this post you would need a PhD (or equivalent) or be near completion in a relevant area of protein science. You should have proven experience in: membrane protein expression, purification, crystallisation and structure determination by X-ray crystallography. You will have excellent presentation and written communication skills, and have a proven record in preparation of high quality research publications. You will be highly self-motivated, well-organised and flexible with strong planning and problem solving skills, able to work independently and as part of a team, and to collaborate with colleagues and external collaborators.

This post is fixed-term for 3 years.

You will be required to upload a CV and supporting statement which explains how you meet the selection criteria for the post.

Only applications received before 12.00 noon on 7 November 2016 will be considered.

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South East England