Research Associate

University of Bath - Biology & Biochemistry

(Fixed-term post)

A postdoctoral position in RNA Biology is available in the group of Grzegorz Kudla at the MRC Human Genetics Unit, University of Edinburgh, in close collaboration with Professor Laurence Hurst (University of Bath), to analyse the effects of synonymous mutations on gene expression in human cells.

We will test the hypothesis that the presence of sequence motifs related to splicing can influence expression and that their removal, in heterologous genes lacking a given intron, can aid efficient expression. We will then attempt to manipulate these motifs to optimize the production of heterologous proteins in human cell lines with a view to incorporation of these genes in gene therapy applications.

The experimental part of the project will use state-of-the-art technologies such as synthetic biology, FACS sorting and next-generation sequencing. The data we generate will then be analysed computationally to study the relationships between RNA sequence, structure and expression.

For more information about the techniques used in our labs, please see Puchta et al., Science 2016.

The position is funded by the European Research Council for a period of up to 4 years, with the starting date in January 2017.

Further details:
Share this job
  Share by Email   Print this job   More sharing options
We value your feedback on the quality of our adverts. If you have a comment to make about the overall quality of this advert, or its categorisation then please send us your feedback
Advert information

Type / Role:


South West England