University of Bath - Biology & Biochemistry
|Salary:||£32,004 to £38,183|
|Contract Type:||Contract / Temporary|
|Placed on:||11th October 2016|
|Closes:||8th November 2016|
We will test the hypothesis that the presence of sequence motifs related to splicing can influence expression and that their removal, in heterologous genes lacking a given intron, can aid efficient expression. We will then attempt to manipulate these motifs to optimize the production of heterologous proteins in human cell lines with a view to incorporation of these genes in gene therapy applications.
The experimental part of the project will use state-of-the-art technologies such as synthetic biology, FACS sorting and next-generation sequencing. The data we generate will then be analysed computationally to study the relationships between RNA sequence, structure and expression.
For more information about the techniques used in our labs, please see Puchta et al., Science 2016.
The position is funded by the European Research Council for a period of up to 4 years, with the starting date in January 2017.Further details:
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South West England