Postdoctoral Training Fellow in Retrovirology

The Francis Crick Institute

Stoye Lab

This is a full-time, fixed term position for 4 years on Crick Terms and Conditions of Employment.


The Francis Crick Institute (the Crick) is a partnership between the Medical Research Council (MRC), Cancer Research UK (CRUK), the Wellcome Trust, University College London (UCL), Imperial College London and King’s College London. It is a registered charity whose purpose is to conduct biomedical research into all aspects of human health and disease.

The institute will be a world-leading centre of biomedical research and innovation. It will promote connections between researchers and disciplines and between academic institutions, healthcare organisations and businesses. Dedicated to research excellence, the institute will have the scale, vision and expertise to tackle the most challenging scientific questions underpinning health and disease. It will be world-class with a strong national role — training scientists and developing ideas for public good. On 1 April 2015, staff from the London Research Institute (CRUK) and National Institute for Medical Research (MRC) transferred to the Crick to form a fully functional research institute on four sites. In 2016, the Crick will move to a single new, purpose-built research centre in St. Pancras which will house some 1,500 staff.

We seek a talented and motivated postdoc in Virology to join Jonathan Stoye’s group in the Laboratory of Retrovirus-Host Interactions.


Dr Stoye’s laboratory focuses on the study of host restriction factors and viral countermeasures.  An overview of work currently being undertaken can be seen at:  His laboratory interacts closely with that of Ian Taylor (


  • The proposed research aims to understand the evolution and function of the Capsid binding retrovirus restriction factors Fv1 and TRIM5α.

Specific objectives will include, but not be limited to:

  • Determining the multimerization status of Fv1
  • Identifying sequences important for Fv1 localization
  • Examining the physical interaction between Fv1 and TRIM5α and their targets

Person Specification: The post holder should embody and demonstrate our core Crick values: Bold, Imaginative, Open, Dynamic and Collegial, in addition to the following:


  • A PhD or near completion in virology, microbiology or related discipline
  • Comprehensive skills in molecular biology and cell biology
  • Training in growth and assay of viruses
  • Track record of writing papers as evidenced by publications or submitted manuscripts in referred journals
  • Evidence of data presentation at scientific meetings
  • Experience of experimental design
  • Ability to work independently and also capable of interacting within a group


  • Good knowledge of retrovirus replication.
  • Experience of working with pathogenic agents
  • Training in biochemistry and microscopy

All Postdoctoral Training Fellows are expected to lead on their own projects and contribute to other projects on a collaborative basis, both within the laboratory and with collaborators. The ability to work as part of a team is essential.

Please note: All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.

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