PhD Studentship: Chemokine receptors as new targets in breast cancer metastasis (MUELLER_U17SCI)

University of East Anglia - School of Pharmacy

Start Date: October 2017

Supervisor: Dr Anja Mueller

Project description:

Chemokines are important for the recruitment of leukocytes to the tumour microenvironment which can affect invasion and metastasis. Chemokine receptors are overexpressed in a variety of different cancers and they play a role in cancer cell homing and metastasis. However blocking the receptors directly has not been proven to be successful in clinical trials so far. This makes the receptors itself a less than ideal drug target and consequently targeting the signalling networks which are activated by these receptors might be a more successful route of preventing metastasis. In this project we will investigate which receptors are involved in breast cancer metastasis and will identify which signalling networks become activated. We will use cell biological based assays to assess cell migration, compared with pharmacological experiments to identify different signalling partner and assess their importance in migration.

Informal enquiries are welcomed; for further information please contact Dr Anja Mueller (

Interviews will take place between 16 January and 24 February 2017.

Person specification: The successful applicant will have, or expect to obtain a first class, 2(i) or equivalent Honours degree in Pharmacology, Biochemistry, Pharmacy or a related area.

Funding notes: This PhD project is in a Faculty of Science competition for funded studentships. These studentships are funded for 3 years and comprise home/EU fees, an annual stipend of £14,296 and £1000 per annum to support research training.  Overseas applicants may apply but they are required to fund the difference between home/EU and overseas tuition fees (in 2016/17 the difference is £12,879 for the Schools of CHE & PHA, and £9,679 for CMP & MTH but fees are subject to an annual increase)

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South East England