Research Associate - Synthetic Chemistry

University of Cambridge - Department of Chemistry

2 Posts

Applications are invited for two post-doctoral research associates to work with Professor Christopher Hunter in the Department of Chemistry at the University of Cambridge to work on an EPSRC programme to develop new PET markers for imaging misfolded proteins involved in neurodegenerative disorders. The appointees will join a multidisciplinary team of several post-docs and PhD students based in Cambridge combining expertise in supramolecular chemistry, organic synthesis, polymer chemistry and computational chemistry.

The aim of the project is to develop the next generation of PET probes for imaging misfolded pathogenic proteins in humans focusing on the development of specific markers for oligomeric forms of these proteins. The appointees will work as part of a larger team in collaboration with the research groups of Professors Klenerman (Biophysical Chemistry), Spillantini (Clinical Neurosciences) and  Aigbirhio (Wolfson Brain Imaging Centre). The project will involve the synthesis of libraries of ligands and testing their binding affinity for beta-amyloid, tau and alpha-synuclein proteins. The most promising compounds will be developed as in vivo PET probes. The main focus of the role is the design and synthesis of new compounds, and the appointees will interact with other members of the team for biological testing and development of PET probes.

Applicants should have (or be about to obtain) a PhD in chemistry. Experience in some or all of organic synthesis and supramolecular chemistry is required. The appointees will be expected to give oral presentations on their work, write internal reports and produce draft publications, and relevant communication skills are required. In addition to their own research, the appointees will be expected to take some responsibility for the supervision and training of post-graduate and undergraduate research students and for the day-to-day running of the laboratory.

Fixed-term: The funds for this post are available for 1 years in the first instance.

To apply online for this vacancy and to view further information about the role, please visit: This will take you to the role on the University’s Job Opportunities pages. There you will need to click on the 'Apply online' button and register an account with the University's Web Recruitment System (if you have not already) and log in before completing the online application form.

Please ensure that you upload your Curriculum Vitae (CV), a covering letter and publications list in the upload section of the online application. If you upload any additional documents that have not been requested, we will not be able to consider these as part of your application.

For queries regarding applying online for these posts, please contact Dr M Cristina Misuraca (

Please quote reference MA10430 on your application and in any correspondence about this vacancy.

The Department holds an Athena SWAN silver award for women in Science, Technology, Engineering, Mathematics, and Medicine.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

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South East England