Postdoctoral Researcher in Cancer Bioinformatics

INSERM - Cancer Research Center of Marseille

Contract: Full-time postdoctoral for 1.5 years in the first instance

Starting Date: January-February 2017 

Working environment
The Cancer Research Center of Marseille (CRCM) is the basic science and translational research unit of the private cancer hospital Institut Paoli Calmettes (IPC). Also affiliated to INSERM, CNRS and Aix-Marseille University IPC and CRCM form part of the comprehensive cancer centre Marseille SIRIC (http://www.siric-marseille.fr/Les-SIRICS.html).

Project
This project aims at identifying predictive markers of ex vivo drug sensitivity in Acute Myeloid Leukemia (AML). The successful candidate will investigate the application of machine learning methods to predict which drugs are most effective for a given AML tumour exploiting in-house and public data resources.

Further information: http://crcm.marseille.inserm.fr/en/researchteams/pedro-ballester/.

Informal enquiries to pedro.ballester@inserm.fr

Selection criteria – Essential

  • A PhD degree with a major focus on computational analysis of experimental data, preferably in an area directly relevant to the project.
  • Experienced in the application of machine learning to solve real-world problems in the context of biomedical research.
  • Skilled in the implementation of R or Python scripts for scientific data analysis.
  • Ability to undertake high quality scientific research as demonstrated by publications.
  • Ability to communicate effectively in English, both orally and in writing.

Selection criteria – Desirable

  • A track record of publications in AML, modelling of cancer pharmacogenomics and/or biomarker discovery will be a strong advantage.
  • Experienced or trained in handling, integrating, processing and analysing NGS data (especially DNA-seq, RNA-seq and ChIP-seq).
  • Software engineering skills using C++, C and/or Python (numPy/SciPy/scikit-learn) including version control tools (e.g. git or mercurial).
  • Working knowledge of open-source chemoinformatics toolkits (e.g. RDKit or OpenBabel) and medicinal chemistry databases (e.g. ChEMBL and ZINC).
  • Hands-on experience in the design and implementation of relational databases using MySQL and/or PostgreSQL as well as in web programming.

What we offer
The successful candidate will join the Ballester group at the CRCM. This is a recently created group, which will have nine members with the arrival of the post holder in January 2017 (group leader, three postdoctoral researchers, four PhD students and one master student). Thus, there will be opportunities for the post holder to collaborate with other team members.

The successful candidate can be supported to apply for a permanent research scientist position (e.g. Inserm CR2 or CNRS CR2) to be held within the Ballester group. Currently, three CRCM candidates per year are successful in being awarded these permanent positions. In terms of quality of life, the CRCM is located in Marseille and thus the post holder will enjoy living in an exciting multi-cultural city right by the French Mediterranean coast.

How to apply
Candidates must send a CV including a list of peer-reviewed publications and a covering letter (maximum two pages) to pedro.ballester@inserm.fr with subject line “cancer bioinformatics position”. This letter will explain how they meet the essential selection criteria, which desirable selection criteria are also met and how this position would fit in their future career plans. This email must also state the names and emails of three scientists familiar with their research, who are willing to provide a reference. Please also mention in the letter where did you see this position advertised.

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