Marie Skłodowska-Curie Early Stage Researcher

University of Sheffield - Department of Infection, Immunity and Cardiovascular Disease

Contract Type: Fixed-term for three years
Faculty: Faculty of Medicine, Dentistry & Health
Salary: £26,200 per annum, plus a Mobility Allowance of £478 per month and a Family Allowance (if eligible) of £398 per month

Dysregulation of common molecular pathways that govern the physiological functioning of adipocytes, immune cells and prostate epithelial cells have been reported in immunometabolic diseases, such as obesity, and several cancers. Our overall objective is to uncover cell-specific aspects of these pathways, focusing on tribbles (TRIB) proteins, a recently described family of pseudokinases, that have a key role in controlling immunity, energy homeostasis and cancer development, and which here will serve as prototypical examples for integrative immuno-metabolomic cancer research.

The Early Stage Researcher appointed for this post will carry out a three-year research programme towards a PhD which will focus on discovery and characterisation of miRNAs that regulate the expression of TRIB proteins in monocytes and macrophages. The work builds on our recent (unpublished) studies demonstrating a critical role for TRIB proteins in blood myeloid cells and in shaping tissue macrophage phenotype in vitro as well as in vivo. The project will characterise how TRIB expression is controlled by miRNAs in monocytes and macrophages and how these changes govern cell function using in vitro assays as well as next generation sequencing of miRNAs from primary monocytes and macrophages.

This research opportunity is available within the Inflammatory Signalling Group, Department of Infection, Immunity and Cardiovascular Disease. The research forms part of the pan-European TRAIN Marie Skłodowska-Curie European Training Network funded by the European Commission Horizon 2020 programme, which the University of Sheffield co-ordinates. TRAIN (http://www.TRAIN-ITN.eu/) is taking a multidisciplinary but highly integrated approach to provide a better understanding of critical drivers for obesity linked to systemic chronic inflammation and to define the impact of these processes on the cancer development. Ultimately, our programme is aimed at discovering novel targets for future therapeutic interventions in these areas. This Sheffield based project will also benefit from the wider programme of research within our Department (http://www.sheffield.ac.uk/iicd) and the Florey Institute (http://www.sheffield.ac.uk/2022/florey), focussing on regulatory mechanisms of innate immunity, both during infections and chronic inflammatory disease.

The candidate will be expected to integrate their research topic within the collaborative research agenda of TRAIN, building links with network partners in other EU states and from the industrial and clinical sectors.

Applicants should hold a first degree in biological sciences. In addition, MSCA specific eligibility criteria applies; see box below for details. The post is full time and available for three years. The post-holder will report to Dr Endre Kiss-Toth, and Dr Heather Wilson, Inflammatory Signalling Group, Department of Infection, Immunity and Cardiovascular Disease, The University of Sheffield.

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