Research Associate in Computational Biology And Gene Regulation (Fixed Term)

University of Bath - Biology & Biochemistry

Applications are invited for a BBSRC-funded postdoctoral position to join the laboratory of Dr Keith Vance at the University of Bath. We are looking for a self-motivated, enthusiastic computational biologist to work on a multi-disciplinary project investigating genome-wide mechanisms of long non-coding RNA (lncRNA) transcription and chromatin regulation.

We previously showed that the CNS expressed lnc RNA Paupar interacts with chromatin at up to 2,800 sites across multiple different chromosomes to control large scale gene expression programs. Paupar binding sites overlap transcriptional regulatory elements and are enriched within close genomic proximity to genes of known stem cell and neural function (Vance et al.(2014) EMBO J). In this project, we will now perform chromatin conformation capture and high throughput sequencing experiments to map genome wide interactions with the Paupar locus, and with the promoters of key neuronal transcription factors, in neural stem cells and primary neurons. This will enable us to:

  1. Determine the role of nuclear organisation and chromatin structure in guiding Paupar to its target genes.
  2. Investigate the function of Paupar in controlling chromatin conformation.
  3. Characterise the DNA regulatory elements that control the expression of Paupar and selected neuronal transcription factors.

The successful candidate will be a key member of the laboratory and will perform the computational component of this project. This person should have a PhD in computational biology or a related discipline, good scripting/programming skills, and practical experience using bioinformatics methods to analyse genomic and transcriptomic data types such as ChIP-seq and RNA-seq. A willingness to work as part of a multi-disciplinary team is essential for this project. Prior experience in the computational analysis of chromatin architecture would be an advantage but is not required.

This post is offered on a full-time, fixed-term (up to 24 months) contract, and is available from February 2017. Informal enquires are welcome and should be directed to Dr Keith Vance (k.w.vance@bath.ac.uk) however application should be made online.

The University of Bath and our Department, which holds an Athena SWAN bronze award, are committed to equality of opportunity. We encourage applications from under-represented groups, including women.

For further details (Job Description & Person Specification and Terms of Employment) please click the 'apply' link below.

Bath, proud to be an Equal Opportunities Employer, Best Campus University and 1st for Student Satisfaction.

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South West England