Research Fellow in Signalling and Epigenetic Regulation

University of Southampton - Biological Sciences Research

Location:  Highfield Campus 

Full Time, Fixed Term (3 years)

Interview Date:   To be confirmed

We are looking for a Research Fellow to use state of the art epigenetic studies and cell biological techniques to investigate how phosphoinositide signalling lipids impact on the function of epigenetic regulators to modulate nuclear functions such as transcriptional output and cell fate.

This research study is intended to investigate how a family of signalling lipids called phosphoinositides are regulated in the nucleus in response to environmental stimuli and how this impacts on cell behaviour by regulating epigenetic signalling and chromatin dynamics. The project will use state of the art molecular technologies such as CRISPR CAS and imaging studies to understand how phosphoinositides change in the nucleus. The fellow will collaborate with the Nuclear Dynamics groups headed by Dr. P. Fraser based at the Babraham campus in Cambridge to study the impact  of changes in nuclear phosphoinositides on long range chromatin dynamics. 

The applicant should have expertise in epigenetic signalling mechanisms and computational knowledge for the analysis of genomes and CHIP_seq data would be desirable. This post is suitable for biochemists and cell biologists with an interest in epigenetic regulation.

Southampton University is a world leading research university with 97% of its research work assessed as world leading and internationally excellent in the REF 2014 assessment. UOS is a Russell group member and its research impacts on government policy making, health issues, teaching and on business.

The work will take place at the main University campus, in Building 85, which was recently constructed (2008; £47M) to house Biological Sciences researchers, and those who conduct multidisciplinary research in any aspect of life sciences. At the University of Southampton, we value diversity and equality. Please visit to learn more.

Applications will be considered from candidates who are working towards or nearing completion of a relevant PhD qualification. The title of Research Fellow will be applied upon completion of PhD.  Prior to the qualification being awarded the title of Senior Research Assistant will be given.

Application procedure For additional information/informal enquiries before submitting your application, contact Dr Nullin Divecha (   

In your application, please include a covering letter and full CV, and please arrange for two letters of recommendation to be sent in by your referees.

You should submit your completed application form online at The application deadline will be midnight on the closing date stated above. References are requested along with your application, so please allow time for these to be received prior to the close date, to assist the department with shortlisting. If you need any assistance, please call Anna Shikhareva (Recruitment Team) on +44 (0) 23 8059 9002. 

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South East England