Research Associate / Fellow in Stem Cell and Cardiomyocyte Biology (ftc)

University of Nottingham - Cancer & Stem Cells

Location: University Park
Salary: £26,052 to £38,183 per annum, depending on skills and experience (minimum £29301 with relevant PhD). Salary progression beyond this scale is subject to performance

Applications are invited for the above post to join the Department of Stem Cell Biology based within the School of Medicine, University of Nottingham. The department comprises a team of scientists with an interest in combining a range of state-of the art stem cell technologies to answer key biomedical questions, including those relating to heart disease. The post will collaborate extensively with colleagues at the University of Cardiff/Swansea, as well as other academic and industrial centres.

Catecholaminergic polymorphic ventricular tachycardia (CPVT) can be caused by RyR2 dysfunction and is a major cause of arrhythmia and fatalities in patients. The divergent mechanisms of channel dysfunction impact on the efficacy of drug regimens used to treat this condition. Building on experience in our lab, the successful candidate will use Cas9/CRISPR gene editing to generate isogenic controls or mutated lines in human induced pluripotent stem cells (hiPSCs). These engineered hiPSC lines will be differentiated into cardiomyocytes to enable mechanistic and phenotypic evaluation, which will become a major part of the project. This will include molecular (qPCR, RNAseq), structural (shape, size, sarcomere alignment), functional (mitochondria, calcium, electrophysiology, contraction) and pharmacological analyses. The successful candidate should have a strong understanding in one or more of these areas, preferably with experimental expertise.

Candidates should be nearing completion of a PhD or hold a PhD in Biological Sciences or equivalent. The appointed candidate is likely to have a good publication track record and will have presented the data in seminars to international audiences of scientists and the public. They will have a proven ability to collaborate with other institutions and work in a team. Full details are in the job specification.

This full time post will be offered on a fixed-term contract with start date on (or soon after) 30 January 2017 and end date of 30th September 2020.

Informal enquiries may be addressed to Professor Chris Denning, tel: 0115 8231231 or email chris.denning@nottingham.ac.uk. Please note that applications sent directly to this email address will not be accepted.

The University of Nottingham is an equal opportunities employer and welcomes applications from all sections of the community.

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Midlands of England