University of Nottingham - Respiratory Medicine
|Salary:||£29,301 to £38,183 per annum|
|Contract Type:||Contract / Temporary|
|Placed on:||18th November 2016|
|Closes:||19th December 2016|
Location: UK Other
Salary: £29,301 to £38,183 per annum, depending on skills and experience. Salary progression beyond this scale is subject to performance.
Applications are invited for the above post in the Division of Respiratory Medicine, University of Nottingham, based at the City Hospital Campus. The successful candidate will join an excellent team of researchers with a strong track record in basic and translational research in tissue fibrosis and remodelling.
This exciting new post is funded by the Medical Research Foundation and aims to investigate the molecular mechanisms through which the transcription factor Elk1 regulates fibrosis in the incurable and fatal lung disease, idiopathic pulmonary fibrosis. Previous work from the group has highlighted a novel role for Elk1 in repressing lung fibrosis via actions on epithelial αvβ6 integrins, and that expression of Elk1 is reduced in patients suffering from IPF. This project will build upon these findings and aims to identify other molecular pathways normally regulated by Elk1 and therefore become dysregulated in IPF. The candidate will use state of the art molecular biology approaches, including gene microarray analysis, chromatin immunoprecipitation assays and site directed mutagenesis of promoter regions, to investigate which cellular pathways are regulated by Elk1 in mouse and human lungs. The candidate will also utilise in vivo models of lung fibrosis to investigate whether loss of Elk1 contributes to severe and persistent fibrosis.
The successful candidate will have recently obtained a PhD in a related area and must demonstrate a skill set suitable for the post with expertise in molecular biology approaches including chromatin immunoprecipitation and microarray analyses. Additionally, it is desirable that the candidate will have experience of in vivo models of disease. Some knowledge of biostatistics is desirable. The role holder will be supervised by Dr Amanda Tatler, a Senior Research Fellow within the group.
This post will be offered on a full time 2 year fixed-term contract.
Applications will also be considered for part time (min 25 hours per week) or on a fractional basis (min 40 weeks per year).
Informal enquiries may be addressed to Dr Amanda Tatler tel: 0115 8231683 or email Amanda.Tatler@nottingham.ac.uk. Please note that applications sent directly to this email address will not be accepted.
The University of Nottingham is an equal opportunities employer and welcomes applications from all sections of the community.
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Type / Role:
Midlands of England