Research Associate in Synthetic Biology / Metabolite Engineering of Actinomycetes

The University of Manchester - School of Chemistry

Closing Date : 09/01/2017.
Employment Type : Fixed Term.
Duration : 01/03/2017 until 28/02/2019.
Faculty / Organisational Unit : Science & Engineering.
School/Directorate : School of Chemistry.
Division : Manchester Institute of Biotechnology.
Hours Per week : 1 FTE.
Salary : £30,738 to £37,768 per annum.
Location : Oxford Road, Manchester.
Job Reference : S&E-09215.

This is an exciting opportunity to work on the H2020 funded “TOPCAPI: Thoroughly Optimised Production Chassis for Advanced Pharmaceutical Ingredients” project based within the Manchester Institute of Biotechnology.

This project involves a total of 8 academic and industry partners from 4 different EU countries. The aim of the TOPCAPI project is to exploit the natural fabrication power of actinomycetes as microbial cell factories to produce high-value pharmaceutical ingredients.

You will have skills in synthetic and/or molecular biology allied to strong interests in genome editing. You will join a team of researchers in the TOPCAPI consortium, in particular with another PDRA and technician based in the Manchester Institute of Biotechnology. The project will be working to exploit actinomycete to produce high-value pharmaceutical ingredients, in particular the starter compound for the semi-synthesis of a new topical anti-acne drug currently in Phase II clinical trials, and intermediates for the semi-synthetic production of medically important type II polyketide tetracyclines to be used against methicillin-resistantStaphylococcus aureus infections (MRSA). A strong commitment to team-based work is required with strong background in synthetic biology, molecular biology and Actinomyces genetics. This 4 years project will be supervised by Professor Eriko Takano.

You will hold a PhD (or equivalent) in Biology/Biochemistry (or a related subject area), and have technical skills in synthetic and/or molecular biology, metabolic engineering allied to strong interests in genome editing.

The School is strongly committed to promoting equality and diversity, including the Athena SWAN charter for gender equality in higher education. The School holds a Silver Award which recognises their good practice in relation to gender; including flexible working arrangements, family-friendly policies, and support to allow staff achieve a good work-life balance. We particularly welcome applications from women for this post. Appointment will always be made on merit. For further information, please visit:

The University of Manchester values a diverse workforce and welcomes applications from all sections of the community

Please note that we are unable to respond to enquiries, accept CV's or applications from Recruitment Agencies.

Enquiries about the vacancy, shortlisting and interviews:

Name: Professor Eriko Takano


Tel: 0161 306 4419

This vacancy will close for applications at midnight on the closing date.

Further Particulars

Further particulars including job description and person specification are available on the University of Manchester website - click on the 'Apply' button below to find out more.

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