Research Associate in Computational Clinical Electrophysiology Modelling

King's College London - Department of Biomedical Engineering

The salary will be paid at Grade 6, £32,958 to £39,324 per annum, plus £2,623 per annum London Allowance depending on qualifications

This post will be a Fixed Term for 24 months

King’s College London with its 200 years of heritage is recognised today as a world-leading research university, ranked 7th in the 2014 Research Excellence Framework. We understand the need to turn original thinking into everyday application, encouraging curiosity to develop work that makes an impact on society and global issues. Great names from King’s are continuing to change the world.

Identification of optimal targets for catheter ablation of ventricular arrhythmias in a safe and robust manner remains a significant clinical challenge. We have recently developed a novel substrate mapping procedure which utilises both activation and repolarisation time information to identify ablation targets. This method may significantly improve substrate mapping for reentry vulnerability without the need for arrhythmia induction, but requires essential further development to enable its incorporation into a robust and accurate clinical protocol. We propose to use advanced computational simulations to identify optimal pacing and analysis procedures for this method. In conjunction with improvements to clinical data acquisition and processing, the optimised procedure will be tested, retrospectively, on a cohort patients receiving ablation therapy.

The successful candidate will perform detailed computational investigations to help optimize our novel clinical technique for mapping the electrical functioning of the heart in order to improve catheter ablation therapy of incessant cardiac arrhythmias. The post-holder will be primarily responsible for creating high-resolution computational cardiac models of patients with ischemic heart disease, performing simulations with these models which replicate the clinical mapping procedure and analyzing and interpreting the results. The post will use the computational and clinical electrophysiological infrastructure provided by the Division of Imaging Sciences and Biomedical Engineering and will be based at St Thomas’ Hospital. This project, funded by the BHF, is suited to an individual with experience in cardiac physiology research, the creation and simulation of cardiac electrophysiology models, the processing of MR/electrophysiology data and the use of high-performance computing resources.

Located in the heart of London, King’s is the hub of a global network of strong academic connections and collaboration, with prestigious international partnerships within and across disciplines – scientific and medical, social and creative. King’s is investing in the highest calibre of talent to drive the university forward to achieve its greatest potential. The very best from the United Kingdom and across the globe are invited to join King’s. We are looking for a strong commitment to teaching and research, to push the boundaries of knowledge, influence the future and create a lasting impact.

The selection process will include a panel interview and a short presentation. Interviews are scheduled to be held the week commencing: 5th December, 2016

For an informal discussion to find out more about the role please contact Dr Martin Bishop, Department of Biomedical Engineering:; 020 7188 7188 ext 53219

To apply for this role, please go to the King’s College London HireWire Job Board and register to download and submit the specified application form.

The deadline for applications is midnight on 18 December 2016

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