Scientist (Structural Cell Biology )

University of Dundee - Biological Chemistry and Drug Discovery

We are currently looking for a highly motivated structural biologist to join a team of five scientists as part of an exciting new drug discovery collaboration between Professor Alessio Ciulli (http://www.lifesci.dundee.ac.uk/people/alessio-ciulli-0) and Boehringer Ingelheim (BI). Our mission is to discover and develop a class of small-molecule drugs for targeted protein degradation as a novel therapeutic paradigm to treat cancer and other human diseases with serious unmet medical needs (https://goo.gl/kpnzBc).

The post is available immediately and salary will depend on experience, but will be up to £38,183. This is a unique opportunity to gain experience in industry-style drug discovery within an academic setting.

Your responsibilities:

  • Characterise the binding of small molecule PROTACs to their Target Protein and E3 ligases and components using X-ray crystallography amongst other structural methods.
  • Develop and apply biophysical and biochemical assays in vitro to profile novel compounds (including proximity and fluorescence-based assays, ITC, SPR, NMR and BLI amongst others).
  • Drive the structure-guided design of PROTACs by determining structure-activity relationships in vitro and in living cells.
  • Carrying out data analysis and relevant quality assurance protocols.
  • Report directly to the Team Leader and to the Principal Investigator (Prof. Ciulli).

Your qualifications:

  • A PhD in structural biology, biophysics, biochemistry, molecular biology or a related discipline is required.
  • Outstanding academic or industrial track records are strongly desired.
  • Strong background in protein purification and crystallization, X-ray data collection (in-house and at synchrotrons), structure solution and model refinement is essential.
  • Strong interpersonal, communication and presentation skills are essential.
  • A track record of problem solving within a team environment is essential.
  • Experience with biophysical techniques to study protein-ligand and protein-protein interaction are strongly desired.
  • Experience with protein ubiquitylation assay would be an advantage.

This post is available for a fixed term period of 18 months in the first instance, with the possibility of being renewed for another 18 months.

Additional Information

The University of Dundee is a diverse community and is committed to equality of opportunity for all by providing a supportive, flexible and inclusive working environment.  We have family friendly policies (including flexible working and childcare vouchers), staff groups for LGBT and BME; and prayer room facilities.

The University of Dundee has received the Athena SWAN Bronze Award (Athena Swan) which recognises the promotion of gender equality and has made further commitment to advancing inclusive culture which supports and encourages all under-represented groups.

The University of Dundee is a Scottish Registered Charity, No. SC015096.

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