Post Doctoral Training Fellow in Testicular Cancer Team

Institute of Cancer Research - Genetics & Epidemiology, Molecular & Population Genetics

A postdoctoral research position is available to work on projects to identify and explore the functional basis of mutations associated with Testicular Germ Cell Tumour (TGCT). We seek a highly motivated candidate with a PhD and background in genomics and molecular biology. The successful candidate will lead on the TGCT laboratory and analytical work, supported by a Scientific Officer. The post is situated within and supported by the Houlston Molecular and Population Genetics Team, a large group with broad bioinformatics and wet-lab expertise in which novel analytical approaches to susceptibility, somatic and functional genomic are applied across a range of tumour types. This is an ideal opportunity for a highly skilled post-doctoral researcher to enjoy autonomy, varied laboratory and analytical projects and rich opportunity for primary authorships, supported and educated by the work and expertise of the larger group. Applicants should have broad laboratory skills as well as experience of applying statistical and bioinformatics analyses to genomic data.

The Testicular Cancer Team at the ICR has had lead the world field in the identification and characterisation of genes and variants that predispose to testicular cancer, including publication of the first large-scale NGS analysis of TGC tumours, the first large-scale WES analysis of TGC susceptibility and the largest GWAS analyses for TGCT (see recent publications ).

We hold >10,000 samples from men with TGCT, far and away the world’s largest sample series. We have GWAS data from >5000 cases of TGCT, germline exome data on >1000 cases of TGCT and are initiating WGS of TGCT cases. We also have large series of matched tumour and germline pairs and WES data on unselected and platinum resistant TGCTs. We have lead a number of successful international collaborative experiments and currently work within an active international consortium.

The post-holder will work on varied projects directed towards identifying mutations contributing to the development of Testicular Germ Cell Tumour (TGCT) and exploring their functional basis.

Primarily the project will involve:

(i) Applying a range of laboratory approaches to functionally characterise the mechanisms and pathways by which germline variants confer susceptibility to TGCT

(ii) Application of WES, WGS and GWAS approaches to identify and validate novel germline variants contributing to susceptibility to TGCT

In addition, for an applicant with appropriate interest and experience, there are opportunities for:

(iii) Integrating NGS sequencing and Oncoscan array genotyping to identify and validate novel somatic variants in platinum resistant TGCTs.

(iv) Applying bioinformatic and laboratory approaches to functionally characterise the mechanisms and pathways by which mutations contribute to the pathogenesis and drug resistance of TGCT.

The post-holder would be expected to bring genomic and molecular biology research experience to studies. The post-holder would be expected to bring well-developed skills in data analysis and bioinformatics to studies, although there is very strong bioinformatics support within the group by which these skills can be further nurtured. The post-holder will be expected to interact with, and supervise, junior team members, together with other senior researchers.

Please click apply for further information and to apply

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