Postdoctoral Researcher in Cardiovascular Science

University of Sheffield - Department of Infection, Immunity and Cardiovascular Disease

Contract Type: (applicable if not open-ended) Fixed-term for 18 months

Faculty: (if applicable) Faculty of Medicine

Location: (applicable if not main campus) Inflammatory Signalling Group

Summary:

Hepatic lipogenesis is a tightly regulated process. Excessive production of cholesterol and secretion of lipoprotein particles leads to elevated plasma lipid levels, a major risk factor in the development of atherosclerosis. The pseudokinase TRIB1 has previously been associated with the risk of hyperlipidaemia in genome-wide association studies. Most recently, studies in mouse models of hyperlipidaemia have shown that hepatic TRIB1 deficiency increases lipogenesis and results in elevated plasma lipid levels. However, much less is known about how TRIB levels are controlled in hepatocytes.

The Postdoctoral Scientist appointed for this post will carry out an 18 month, BHF funded research programme towards which will focus on characterising the role specific microRNAs may play in the regulation of TRIB1 expression and their ultimate impact on hepatic lipogenesis and lipoprotein secretion. The work builds on our recent (unpublished) studies demonstrating a critical role for a number of miRNAs in controlling hepatic TRIB expression. The project will focus on understanding the molecular mechanisms for these changes using in vitro assays as well as exploring the impact of protecting hepatic TRIB1 mRNA by blocking the action of specific miRNAs on plasma lipid homeostasis.

This research opportunity is available within the Inflammatory Signalling Group, Department of Infection, Immunity and Cardiovascular Disease. Ultimately, our programme is aimed at discovering novel targets for future therapeutic interventions in these areas. This Sheffield based project will also benefit from the wider programme of research within our Department (http://www.sheffield.ac.uk/iicd), focussing on regulatory mechanisms of cardiovascular disease.

The work will be undertaken within the Inflammatory Signalling Group, Department of Infection, Immunity and Cardiovascular Disease, Faculty of Medicine, Dentistry and Health at the University of Sheffield. The Department is a leading centre for research into the cellular and molecular mechanisms that govern inflammation both in a physiological and pathological setting. It includes modern laboratories and specialised state-of-the-art equipment. The Department also contains dedicated study space for PhD students and post-doctoral scientists.

The candidate will be expected to integrate their research within the Department as well as within the Inflammatory Signalling group, led by Dr Endre Kiss-Toth.

Applicants should hold a first degree in biological sciences and ideally a PhD in a relevant field. As the project is relatively short term, a demonstrated extensive experience in a number of techniques is essential (see details About The Job). The post is full time and available for 18 months. The post-holder will report to Dr Endre Kiss-Toth and Professor Sheila Francis, Inflammatory Signalling Group, Department of Infection, Immunity and Cardiovascular Disease, The University of Sheffield.

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Northern England