Senior Research Associate

University of East Anglia - School of Biological Sciences

Structure activity relationship of P2X4 receptor modulators and their vasomotor activity

A highly motivated Postdoctoral Research Associate is sought to undertake a project funded by the British Heart Foundation. The role requires expertise in patch-clamp electrophysiology, intracellular calcium measurements and previous experience of working with ligand-gated ion channels expressed in mammalian cells. A key task will involve screening of compound libraries against the P2X4 receptor using a Flexstation III instrument and subsequent characterisation of compounds by patch-clamp electrophysiology. Electrophysiological characterisation will include measurement of potency, selectivity and reversibility.  The role also requires expertise in site-directed mutagenesis and the generation of chimeric receptors to study the structure activity relationship underlining modulator activity.

The successful candidate will play a key role in studies of P2X4 allosteric modulators in the cardiovascular system, and join an internationally recognised research team within P2X receptor biology lead by Dr Samuel Fountain. Candidates will have a minimum of a PhD in Pharmacology, Physiology, Biomedicine or a closely related subject, and be able to fulfil all essential elements of the person specification.  

The full time post is available from 1 March 2017 for a fixed term period of 3 years or until 23 December 2019.

Closing date: 12 noon on 4 January 2017.

The University is a Bronze Athena Swan Award holder, currently working towards Silver

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South East England