Research Associate in Computational Biology for Metabolic Engineering

The University of Manchester - Science and Engineering

Applications are invited for a Research Associate to work on the H2020 funded “TOPCAPI: Thoroughly Optimised Production Chassis for Advanced Pharmaceutical Ingredients” project based within the Manchester Institute of Biotechnology. This project involves a total of 8 academic and industry partners from 4 different EU countries. The aim of the TOPCAPI project is to exploit the natural fabrication power of actinomycetes as microbial cell factories to produce high-value pharmaceutical ingredients.

You will have skills in computational biology, aligned with the requirements of synthetic biology and metabolic engineering. You will join a team of researchers in the TOPCAPI consortium, in particular with another (experimental) PDRA and technician based in the Manchester Institute of Biotechnology. The project will be working to exploit actinomycetes to produce high-value pharmaceutical ingredients (antibiotics), using an interdisciplinary integrative strategy, with major input from computer-aided strain and pathway design, quantitative predictive modelling and advanced postgenomic data processing. A strong commitment to team-based work is required with strong background in bioinformatics, metabolic modelling, and transcriptomics and metabolomics data analysis. This 4 years project will be supervised by Professor Rainer Breitling.

You will hold a PhD (or equivalent) in Computational Biology / Bioinformatics / Systems Biology / Chemical Engineering (or a related subject area), and have technical skills in computer programming, postgenomic data analysis, statistics, and systems biology.

The School of CHEMISTRY is strongly committed to promoting equality and diversity, including the Athena SWAN charter for gender equality in higher education. The School holds a Silver Award which recognises their good practice in relation to gender; including flexible working arrangements, family-friendly policies, and support to allow staff to achieve a good work-life balance. We particularly welcome applications from women for this post. Appointment will always be made on merit. For further information, please visit

Please note that we are unable to respond to enquiries, accept CV's or applications from Recruitment Agencies.

Enquiries about the vacancy, shortlisting and interviews:

Name: Professor Rainer Breitling


Tel: +44 (0)161 306 5117

General enquiries:


Tel: 0161 275 4499

Technical support:


Tel: 01565 818 234

This vacancy will close for applications at midnight on the closing date.

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Northern England