Postdoctoral Research Scientist - Structure of the KATP Channel Complex
University of Oxford - Department of Physiology, Anatomy and Genetics
|Salary:||£31,076 to £38,183 Grade 7 p.a.|
|Contract Type:||Contract / Temporary|
|Placed on:||29th November 2016|
|Closes:||19th December 2016|
Department of Physiology, Anatomy and Genetics, Oxford Centre for Gene Function, Parks Road, Oxford
Applications are invited for a Postdoctoral Research Scientist to work with Professors Frances Ashcroft and Simon Newstead, on the 3-dimensional structure of the KATP channel. The aim is to obtain a detailed understanding of the molecular mechanisms by nucleotides and therapeutic drugs regulate channel activity and how mutations lead to neonatal diabetes or hyperinsulinaemia.
You will be responsible for protein production, purification and characterisation, as well structural analysis using X-ray crystallography and/or cryoEM. This will include the collection, analysis and phasing of data to obtain a 3-D high resolution structure. You will perform data interpretation, implement new approaches (if needed), analyse, write up and publish the data, and present it at international meetings.
You will have a PhD/DPhil or equivalent in a relevant area of research and a good academic track record for your career. Substantial knowledge of molecular biology, membrane protein purification, and structural biology is essential. Knowledge of cryo-EM is an advantage.
You will be based in the Oxford Centre for Gene Function, Parks Road, Oxford OX1 3QB. The post is funded for 2 years (by the Wellcome Trust until 30 September 2017, and thereafter by other sources). The start date is negotiable, but not later than 1 February 2017.
The closing date for applications is 12:00 noon on 19 December 2016. Interviews will be held in January 2017.
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South East England