Marie Curie Fellow (Train2Target)

University of Birmingham - Institute of Microbiology and Infection

College of Medical and Dental Sciences

Full time, Fixed Term for 36 months

ESR9 will be recruited as a PhD candidate to explore the molecular characterization of the BAM protein machinery by definition of the precise interactions between the BAM subunits and their interaction with substrate molecules and substrate chaperones.

Start date (planned): 1st April 2017

Application deadline: 15th January 2017

Planned secondments:

Partner: UNIMI, Milan, IT; Length: 3 months

Partner: CNRS-IBS, Paris, FR; Length: 2 months

Partner: AntibioTx, Hørsholm, DK; Length: 2 months

Train2Target is a multidisciplinary European Training Network funded by the European Commission under the Horizon 2020 Marie Skłodowska-Curie Action. Eleven research groups from academia and private sector have come together to address the challenge of the discovery of innovative antimicrobials.

Description

Infectious diseases are still among the top 10 causes of death worldwide. The most relevant factor accounting for the high incidence of infectious diseases is the increase and spread of multi drug resistant (MDR) strains, which is leaving clinicians with very limited options to treat infections especially those from Gram-negative pathogens.

The bacterial cell envelope is still one of the best targets for antimicrobial discovery. Train2Target is an interdisciplinary project aiming at dissecting the biogenesis of the cell envelope of Gram-negative bacteria, in particular peptidoglycan biosynthesis and outer membrane assembly. The assembly of these structures is carried out by sophisticated molecular machines that need to be temporally and spatially orchestrated to ensure proper cell growth and division. The Train2Target project aims to dissect, at the molecular level, the function and coordination of core envelope machineries: to this end interdisciplinary approaches based on an array of genetic, biochemical, biophysical and structural biology techniques will be used. Innovative in vivo and in vitro assays will also be developed to find molecules that alter the function and/or misbalance the coordination of envelope machineries thus providing new drugs to be developed as innovative antibiotics.

The consortium consists of partners with excellent scientific qualifications in multiple disciplines. In total there are 15 open ESR positions within Train2Target. During the appointment secondments will be performed at the premises of other partners to ensure multidisciplinary training and close collaborations.

funded by the European Commission under the H2020 Marie Curie actions (no. 721484), offering attractive packages to the best candidates

  • MSc (or equivalent graduation) in relevant area (e.g. Biology, Chemistry). Good verbal and written communication skills
  • High level analytical capability
  • Ability to communicate complex information clearly
  • Fluency in relevant models, techniques or methods and ability to contribute to developing new ones
  • Ability to assess resource requirements and use resources effectively

Understanding of and ability to contribute to broader management/administration processes

To download the details of this position and submit an electronic application online please click on the Apply Online button below, please quote the appropriate Job Ref in all enquiries, alternatively information can be obtained from www.hr.bham.ac.uk

Valuing excellence; sustaining investment

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Midlands of England