PhD Studentship: Genomics, Evolution and Computational Phylogenetics - The Evolution of Metabolisms that Shaped Life on Earth

University of Bristol - School of Geographical Sciences

The project
The bacterial metabolisms of photosynthesis and nitrogen fixation have shaped life on our planet by contributing to the cycling of carbon and nitrogen in the Earth’s biosphere. While photosynthesis fixes carbon dioxide using different electron donors (e.g., H20, H2S) into carbohydrates, nitrogen fixation transforms atmospheric nitrogen (N2) into a bioavailable source such as ammonium (NH4). Geochemical and biological evidence suggests that photosynthesis 1-3 and nitrogen fixation 4,5 evolved shortly after life originated on our planet. Understanding how these metabolisms evolved through the bacterial domain will give insights into how these processes have shaped biogeochemical cycles. How can we study the evolution of photosynthesis and nitrogen fixation given that they evolved billions of years ago? The evolution of these processes must be studied indirectly, through the phylogenetic comparison of a wide diversity of bacterial lineages. Such an analysis can help elucidate the details of how these processes evolved and when they evolved. Lateral gene transfer — the transmission of genes between different bacterial lineages — has been used to explain the current distribution of these metabolisms on the bacterial tree of life. Alternative explanations might also be possible, such as the differential loss of genes involved in these metabolisms as bacterial lineages diversified.

Using the bacterial tree of life, this project aims to study how and when these fundamental metabolisms evolve. We will use large genomic data sets to study: (1) the evolution of the bacterial linages and (2) the evolutionary patterns for photosynthesis and nitrogen fixation (both vertical and horizontal) across bacterial groups. The Ph.D. student funded by this grant will also have the unique opportunity to not only collect the appropriate data but also to develop new phylogenetic methods.

This student would be co-advised by Dr. Patricia Sánchez-Baracaldo (University of Bristol) who is an expert in the biological/geological data and Prof. John Huelsenbeck (University of California, Berkeley) who is an expert in the development of phylogenetic methods. This is a great opportunity for students interested in evolutionary biology, phylogenetic methods, bioinformatics, and the origin of life.

How to apply
Please make an online application for this project at http://www.bris.ac.uk/pg-howtoapply. Please select ‘Geographical Sciences: Physical (PhD)’ on the Programme Choice page and enter the title of the studentship project ‘The Evolution of Metabolisms that Shaped Life on Earth’ when prompted in the Funding and Research Details sections of the form.

Candidate requirements
At least a 2.1 (Hons) degree or equivalent in a relevant quantitative subject, e.g. microbiology, bioinformatics, population genomics, environmental biotechnology, marine biology, plant molecular biology, genetics, genomics, and computer science. For EU students, English Language IELTS scores of at least 6.5 (no less than 6.0 in any element). A Masters degree in a relevant subject would be desirable but not essential. Computer programming skills in a relevant language, e.g. C/C++, Python, R or Matlab would be an advantage. The award is available for UK or EU students only. 

Contacts
P.Sanchez-Baracaldo@bristol.ac.uk

Share this PhD
     
  Share by Email   Print this job   More sharing options
We value your feedback on the quality of our adverts. If you have a comment to make about the overall quality of this advert, or its categorisation then please send us your feedback
Advert information

Type / Role:

PhD

Location(s):

South West England