Research Assistant in Disease Gene Regulation

University of Oxford - Radcliffe Department of Medicine

MRC Weatherall Institute of Molecular Medicine
John Radcliffe Hospital

Applications are invited for a highly motivated Research Assistant to work in a programme studying the effect of genome sequence variants and predisposition to common diseases. The posts are funded by a Wellcome Trust Strategic Award and is available immediately fixed-term until 28 February 2019.

The aim of this project is follow up on existing GWAS studies combining recent cutting edge developments in the investigation of gene regulation at the genome scale with advanced computational analysis. The advertised position forms part of a new strategic collaboration between two centres of scientific excellence in Oxford, the Wellcome Trust Centre for Human Genetic (WTCHG) and the Weatherall Institute of Molecular Medicine (WIMM). This Strategic Award brings together world-leading experts in computational science and genetics, and clinicians studying patients with anaemia, diabetes and multiple sclerosis, to develop and implement a systematic approach that will link these disease-associated differences in DNA sequence to the genes they control.

Under the guidance of expert researchers the postholder will be responsible with existing team members for the running of the core genomics data generation pipeline of the program. In the initial phase the majority of the data will come from methods to determine chromatin accessibility, chromatin modification and the chromatin conformation of selected critical regions of the genome. Additionally the postholder will be responsible with existing team members for the development and performance of genome editing protocols to ascertain the damaging effect of sequence changes.

You will hold a minimum of a 2:1 degree in biology, genetics, biochemistry or a similar biomedical-related area. Previous experience in basic molecular biology protocols such as DNA purification, PCR and cloning is essential. Experience of next generation sequencing protocol and working on a Unix platform would be beneficial but not essential.

Applications for this vacancy are to be made online. To apply for this role and for further details, including a job description and selection criteria, please see below.

You will be required to upload a CV and supporting statement as part of your online application

The closing date for this position is 12.00 noon on Wednesday 4 January 2017.

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South East England