Staff Scientist

Wellcome Trust Sanger Institute - Department of Biological Sciences

Fixed-term 2 years with possible extension. 

The Human Cell Atlas team at the Wellcome Trust Sanger Institute is looking for an exceptional Staff Scientist to work on projects supporting and delivering this exciting large-scale international initiative. Work in this post will encompass projects involving research and development, optimisation and implementation of cutting-edge techniques and methods that will eventually underlie work towards the Human Cell Atlas. This will require work in single-cell genomics, tissue disaggregation, tissue cryopreservation and methods to analyse gene expression in a spatial context. 

In addition, the successful candidate will be involved in pilot projects to generate data for the first draft of the Human Cell Atlas by performing single-cell RNA-sequencing analyses on human tissue samples. This post will involve extensive interactions with research groups and operational pipelines throughout the Sanger Institute and the Wellcome Genome Campus. 

Essential Skills 

  • PhD (or equivalent) in Biology, Biochemistry or Molecular Biology
  • Ability to independently solve complex scientific/technical problems and manage scientific projects
  • Extensive molecular biology experience
  • Experience manipulating and improving Next Generation Sequencing protocols
  • Ability to work to a high standard with contamination-sensitive assays (whole-genome amplification, PCR)
  • Experience in cell culture techniques
  • Excellent communication skills
  • Self-motivation and diligence 

Ideal Skills 

  • Postdoc experience
  • Experience with single-cell genomics
  • Experience with tissue disaggregation techniques
  • Experience with tissue / cell cryopreservation techniques
  • Experience in bioinformatics analysis of NGS data
  • Understanding of regulatory issues involved in work with human tissues and data
  • Good publication track record 

Other information
We are looking for a flexible and talented experimental scientist with extensive experience and proven success in molecular biology techniques and next generation sequencing. Experience with single-cell genomics, tissue disaggregation and cryopreservation would be beneficial. For informal enquiries, please contact Dr. Mike Stubbington () 

Campus Life
The Sanger Institute is a charitably funded research centre focused on understanding the role of genetics in health and disease. We use state of the art large-scale genomic approaches to drive world-leading projects to uncover the basis of genetic and infectious disease. Our goal is to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens. 

Our Benefits include: Defined Contribution Pension Scheme, Group Income Protection, Healthcare scheme, Childcare Vouchers, Workplace Nursery and 25 days Annual Leave, increasing by one day per year up to a maximum of 30, plus Bank Holidays. We also have a gym, two cafes, dining facilities, and a free campus bus service. Our thriving Sports and Social Club provides many opportunities to meet with people working across the campus. 

Wellcome Trust Sanger Institute welcomes applications from all candidates irrespective of age, disability, gender, gender identity, sexual orientation, race, religion or belief, or marital or civil partnership status. 

Please include a covering letter and CV with your application. 

Closing date for applications:  14th February 2017, however applications will be considered and reviewed on an on-going basis and therefore the post may be filled before the deadline. 

Customer advert reference: 82579