Postdoctoral Research Scientist - Structure of KATP Channel Complex

University of Oxford - Department of Physiology, Anatomy and Genetics


Applications are invited for a Postdoctoral Research Scientist to work with Professors Frances Ashcroft and Simon Newstead, on the 3-dimensional structure of the KATP channel. The aim is to obtain a detailed understanding of the molecular mechanisms by nucleotides and therapeutic drugs regulate channel activity and how mutations lead to neonatal diabetes or hyperinsulinaemia.

You will be responsible for protein production, purification and characterisation, as well structural analysis using X-ray crystallography and/or cryoEM. This will include the collection, analysis and phasing of data to obtain a 3-D high resolution structure. You will perform data interpretation, implement new approaches (if needed), analyse, write up and publish the data, and present it at international meetings. 

You will have a PhD/DPhil or equivalent in a relevant area of research and a good academic track record for your career. Substantial knowledge of molecular biology, membrane protein purification, and structural biology is essential. Knowledge of cryo-EM is an advantage.

You will be based in the Oxford Centre for Gene Function, Parks Road, Oxford OX1 3QB.

This is a fixed-term post funded for 2 years, by the Wellcome Trust until 30 September 2017, and thereafter by other sources.

For informal enquiries contact Professor Ashcroft or Professor Newstead email: or

The closing date for applications is 12.00 noon on 18 January 2017.

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South East England