Research Associate: Development of Transient Processes For Recombinant Protein Production By Mammalian Cells

University of Sheffield

Contract Type: Fixed term for 12 months.
This is an initial 12 month fixed-term contract. During the early stages of the project additional funding will be sought to try to extend the project by 1 - 3 years.
Working Pattern: Full time
Faculty: Faculty of Engineering
Department: Department of Chemical and Biological Engineering
Salary:Grade 7 £30,175 - £38,183 per annum 

Summary:

Chemical and Biological Engineering is a thriving department within the University’s Faculty of Engineering, comprising 34 academic staff, 41 research staff and technicians, 11 support staff and over 500 undergraduate and postgraduate students.  The Department has a vibrant research and teaching culture spanning particle science and technology / nanotechnology, new energy technologies, the environment and applications of post-genomics bioscience for biotechnology and bioprocessing applications.

This project is a collaboration between Absolute Antibodies Ltd, a fast-growing UK company pioneering rapid commercial supply of recombinant antibodies and the Advanced Biomanufacturing Centre at The University of Sheffield.  In this project we will develop new production processes for rapid, cost effective, small-scale production of recombinant proteins by mammalian cells in culture.

The aims of the project are:

  • Cloning and directed evolution of Chinese Hamster Ovary host cell populations functionally adapted for high-level transient production of recombinant proteins.
  • Transient production process design and development for HEK and CHO cell hosts, including comparative evaluation of cell growth media, and statistical optimisation of key transient production variables.

The successful candidate will be expected to lead research in mammalian cell culture technology, including gene transfection and expression and have knowledge of bio biopharmaceutical production process design and development.

Applicants should hold a PhD (or equivalent experience) in Bioscience or Biological Engineering and be able to demonstrate expertise in mammalian cell culture technology, have a proven track-record of gene expression vector component design, construction and functional analysis and statistical design of experiments. It would also be desirable for the successful applicant to have worked in collaboration with biopharmaceutical or biotechnology companies previously.

You can view the supporting documentation by clicking on About the Job and About the University located near the top of your screen.

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Northern England