Research Associate

University of Cambridge - Department of Clinical Neurosciences

An exciting opportunity has arisen to join the Cytosolic Protein Targeting Group at the UK Dementia Research Institute, hosted within the Department of Clinical Neurosciences at the University of Cambridge. This group is headed by Dr Will McEwan and investigates cellular mechanisms that can bring about the selective degradation of pathogenic proteins in the cytosol. A major goal is in using intracellular immunity to selectively target assemblies of tau, a protein which aggregates during Alzheimer's disease.

This position is aimed at investigating the ability of misfolded proteins to propagate in cell-based and in vitro systems. It is funded by IMPRiND, an international consortium which seeks novel therapeutic approaches in Alzheimer's and Parkinson's diseases. The position therefore represents an opportunity to work alongside many of the leading academic and industry groups in the field in a highly collaborative manner.

The post-holder must hold a PhD or equivalent or be in the course of finishing their PhD . A variety of techniques will be employed during the course of the research. This is likely to include mammalian cell culture, recombinant protein production, biophysical techniques and various light and electron microscopy techniques. Experience in several of these is highly advantageous. Experience in the fields of neurobiology or protein misfolding is desirable though candidates with any relevant background will be considered.

If you have any questions about this vacancy or the application process, please contact Heather Carlyon hc388@medschl.cam.ac.uk

Informal enquiries can be directed to Dr Will McEwan wmcewan@mrc-lmb.cam.ac.uk .

Fixed-term: The funds for this post are available for 2 years in the first instance.

To apply online for this vacancy and to view further information about the role, please visit: http://www.jobs.cam.ac.uk/job/14495. This will take you to the role on the University’s Job Opportunities pages. There you will need to click on the 'Apply online' button and register an account with the University's Web Recruitment System if you have not already and log in before completing the online application form.

Please ensure that you upload a covering letter and CV in the Upload section of the online application. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

The closing date for applications is the 27th August 2017 with interviews likely to be week commencing 11th September 2017.

Please quote reference ZE12873 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

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