Research Associate

University of Cambridge - Department of Clinical Neurosciences

An exciting opportunity has arisen to join the Cytosolic Protein Targeting Group at the UK Dementia Research Institute, hosted within the Department of Clinical Neurosciences at the University of Cambridge. This group is headed by Dr Will McEwan and investigates cellular mechanisms that can bring about the selective degradation of pathogenic proteins in the cytosol. A major goal is in using intracellular immunity to selectively target assemblies of tau, a protein which aggregates during Alzheimer's disease.

This position will seek to understand how therapeutic antibodies operate against the spread of tau misfolding through the brain. Particular attention will be paid to the role of TRIM21, the recently discovered, dedicated antibody receptor of the cytoplasm. The work will build on our recent findings that TRIM21 can prevent the spread of tau misfolding (McEwan et al 2017 PMID 28049840). Research in several experimental systems will be performed including cell-based and in vivo settings. Experience in cellular, biochemical or animal techniques is therefore advantageous. The post-holder must hold a PhD or equivalent in a relevant field (or be in the course of finishing their PhD).

If you have any questions about this vacancy or the application process, please contact Heather Carlyon

Informal enquiries can be directed to Dr Will McEwan (

Fixed-term: The funds for this post are available for 3 years in the first instance.

To apply online for this vacancy and to view further information about the role, please visit: This will take you to the role on the University’s Job Opportunities pages. There you will need to click on the 'Apply online' button and register an account with the University's Web Recruitment System (if you have not already) and log in before completing the online application form.

Please ensure that you upload a covering letter and CV in the Upload section of the online application. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

The closing date for applications is the 27th August 2017 with interviews likely to be week commencing 11th September 2017.

Please quote reference ZE12900 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

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