Postdoctoral Research Scientist in Peptide Platform Technology for Enhanced Oligonucleotide Delivery in Duchenne Muscular Dystrophy

University of Oxford - Department of Physiology, Anatomy and Genetics

Applications are sought for a full-time Postdoctoral Research Scientist to be based in the Department of Physiology, Anatomy and Genetics, Oxford. The successful applicant will be funded by Charley’s Fund to undertake a preclinical project utilising peptide delivered oligonucleotides for the therapeutic treatment of Duchenne muscular dystrophy (DMD).

The project is directed by Professor Matthew Wood. His laboratory is renowned internationally for its work on development of peptide-based delivery technology for neuromuscular disorders. The Wood laboratory is a dynamic and highly collaborative environment which very well-funded and fully equipped for state-of-the-art molecular and cell biology.

The Postdoctoral Research Scientist will be responsible of identifying and optimising a lead peptide-oligonucleotide compound suitable for clinical development and evaluation in DMD patients. Project responsibilities include planning and managing experiments, in vivo delivery of oligonucleotides through systemic routes of administration, analysis of drug efficacy through QPCR and western blotting and immunostaining of muscle tissue.

Candidates must hold, or be near completion of, a PhD or equivalent in any area of biological science with experience in the field of muscle biology and models of Duchenne muscular dystrophy. Practical experience with in vivo techniques, including systemic administrations and dissections is essential. Exceptional levels of motivation, innovation and a highly collaborative personality are required to lead this ambitious project along with the ability to work both independently and as part of a research team. The position is an excellent opportunity for a highly ambitious, motivated and innovative scientist to expand their skill-set, with additional training in state-of-the art methods for the study of muscle biology while using advanced therapeutic approaches including next generation oligonucleotide technologies.

The post is for 12 months in the first instance and will be based in the Le Gros Clark building, South Parks Road, Oxford, OX1 3QX.

The closing date for applications is 12.00 noon on Friday 25 August 2017. Interviews are likely to be held on 7 or 8 September 2017.

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South East England