Postdoctoral Scientist x 3 - Neurobiology - Anne Bertolotti

MRC Laboratory of Molecular Biology

The MRC Laboratory of Molecular Biology is a world leader in biological research, with an expanding scientific programme dedicated to understanding gene function in health and disease. It provides an unsurpassed environment for both young and established researchers. Scientists are drawn to the LMB from all over the world, creating a lively and international community for the exchange of ideas and technical innovation.

We are looking for three Postdoctoral Scientists to join Dr Anne Bertolotti’s pioneering research programme, which focuses on innovative approaches to rescue cells from protein misfolding, a condition at the origin of many human diseases, including neurodegenerative diseases. One of such approaches consist in selective inhibition of phosphatases, an important discovery because phosphatases were thought to be undruggable before this work (see Tsaytler et al., 2011, Science, 332, 91-4; and Das et al., 2015, Science, 348, 239-242, Carrara, Sigurdardottir and Bertolotti. In press).

Dr Anne Bertolotti’s cutting-edge work has gained international recognition and she is the recipient of a prestigious Wellcome Trust Investigator Award, to continue innovative and transformative research.

You will join a strong inter-disciplinary team at the LMB which has broad expertise extending from biochemistry, x-ray crystallography, chemical biology, molecular and cell biology through to transgenic animals models of degenerative diseases.  We also have an excellent record of innovative basic research leading to applications in medicine.

You will make a significant contribution to a project aimed at capitalizing on our pioneering discoveries on phosphatases. Available projects range from biochemistry, biophysics and crystallography, cell biology and animal models of neurodegenerative diseases. Further information about the position may be obtained from Dr Anne Bertolotti– email:

You will be ambitious, creative and fearless. You will have a PhD in biochemistry/biophysics/crystallography or molecular or cell biology or due to complete doctoral studies within 6 months of applying. Relevant experience is required and this must be best attested by at least one impactful publication. Experience with biochemistry, biophysics and crystallography is desirable. Experience with ribosome or polysome profiling and RNA seq is desirable. An interest in chemical biology, signaling and/or stress responses as well as an interest in neurodegeneration is desirable.

You will enjoy interacting with a dynamic interdisciplinary team sharing a passion for science and a commitment to explore the unknown.

The successful candidate will be awarded a three-year MRC Career Development Fellowship/MRC Postdoctoral Training Scheme, which is a training and development position for a postdoctoral scientist who has recently completed doctoral studies or is moving into a new research discipline.

Working for the MRC provides a whole host of benefits including a final salary pension scheme, Benenden Healthcare membership and excellent holiday entitlement. You will also have access to employee shopping/travel discounts, on site sport and social facilities, as well as salary sacrifice cycle to work schemes and childcare vouchers. 

For further information of the research undertaken at the LMB, please visit:

To apply and access full details of the vacancy please visit our job board at If you are unable to apply online please contact us at 

This position is subject to a pre employment screening. The Medical Research Council is an Equal Opportunities Employer

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South East England