Research Assistant in Identification of Drug Targets in Acute Myeloid Leukaemia

University of Oxford - Radcliffe Department of Medicine

Radcliffe Department of Medicine, MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford

A unique opportunity for a driven, highly motivated and talented Research Assistant to join the research group of Professor Paresh Vyas at the MRC Weatherall Institute of Molecular Medicine (WIMM).  You will work in a University-industry collaboration to discover and functionally test new lead therapeutic compounds for treatment of the most common aggressive human acute leukaemia, Acute Myeloid Leukaemia (AML). The position is fixed-term until 2 May 2019,  funded by an innovative new spin-out company OxStem Oncology (www.oxstem.co.uk/product-pipeline/oncology) and will involve collaborations with Associate Professor Thomas Milne (WIMM) and the University Department of Chemistry (Professor Steven Davies and Angela Russell).

The Vyas lab has a long-standing interest in the biology of normal and leukaemic stem cells. The Milne lab focuses on epigenetics of haemopoiesis and the Davies/Russell labs have made rich small molecule compound libraries. Traditionally, cancer therapies have focussed on killing tumour cells. In a highly novel approach the applicant will instead focus on identifying molecules that cure leukaemia by releasing the differentiation block in AML using high throughput screens that combine state-of-the-art cell and molecular approaches. The post holder is a key team member who will play a pivotal role in functionally testing lead compounds on primary AML cells in vitro and in vivo 

You will hold a degree in biological sciences (preferably 1st or 2.1) with experience of FACS, haematopoietic stem/progenitor cell cultures and of in vivo models to test human haemopoiesis. Your will have experience of managing your own time to meet project deadlines and to work independently as well as part of a team. Bioinformatics expertise (NGS) is desirable.

Applications for this vacancy are to be made online.  You will be required to upload a CV and supporting statement as part of your online application.

The closing date for this position is 12.00 noon on Thursday 31 August 2017.

https://www.recruit.ox.ac.uk/pls/hrisliverecruit/erq_jobspec_version_4.jobspec?p_id=130283

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South East England