Senior Bioinformatician Flow/Mass Cytometry

Guy's & St Thomas' Hospital NHS Trust

Contract: Fixed term until 31.03.2022

The BRC Flow Cytometry Core at Guy’s and St Thomas’ Hospital/King’s College London is offering a new position for a Senior Bioinformatician. The state of the art Core is focused on biomarker discovery to improve future medical care, gaining a deeper understanding of underlying immunological disease processes and developing assays for better drug discovery. We look for a team member to expand our high dimensional data analysis capacity after adding Imaging Mass Cytometry and next generation fluorescent cytometry (28 parameters) to our portfolio.

Recent technological advances in cytometry, the widespread intensive use of Flow and Mass Cytometry and the spread of –omics approaches in research and clinical settings have led to large data sets of increasing complexity that require novel approaches for analysis and data management. Our new colleague will expertly analyse complex data sets with existing software solutions (e.g. R/Bioconductor, MATLAB, viSNE (t-sne), Spade, FlowJo, Cytobank suite, ImageJ, CellProfiler). S/he will work closely with our large core facility team and together with our Senior Bioinformatician as well as alongside faculty and scientists of all levels. An important aim of the position will be to establish and provide a professionally run high dimensional data analysis capacity for the newly installed Fluidigm Hyperion Imaging Mass Cytometer which is set to transform digital histo-pathology. Where required, s/he will be able to create new analytical software tools for our large and growing user base with a focus on image analysis Thus, the candidate must have a solid knowledge of statistics, mathematics and machine learning approaches for the analysis and visualization of high dimensional biological/biomedical data. The post holder will be involved in training and provide courses for basic and advanced analytical operations and also design in collaboration with the rest of the team streamlined workflows for experimental design, conduct and analysis. S/he must be comfortable working in a multidisciplinary environment, have excellent communication and customer service skills, and be comfortable working independently. There will be opportunities to present at regional and national scientific symposia and workshops. Developing collaborative relationships with leading laboratories is strongly encouraged.

The role calls for a detail oriented and highly motivated individual with project management skills and the ability to deliver to time and target. Qualified candidates will have a PhD (mathematics/bioinformatics or also immunology/histology/related field) and 3+ years of basic research experience using computational approaches. You will have a strong background in mathematics and statistics including expertise using scientific software package such as MATLAB and R. Excellent skills in programming (desired languages: Python, Perl, C/C++, Java), data visualization, machine learning and also software engineering are essential. Ideally, s/he will have worked with bench scientists/been a bench scientist in the past and have an understanding of Flow and Mass Cytometry and thorough grasp of immunology. Prior hands on experience in complex image data analysis is a definite plus.

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