Research Associate in Cell and Molecular Biology

University of York - Department of Biology

We are seeking a highly motivated and talented postdoc to join Dr Ian Hitchcock’s laboratory in the Department of Biology, University of York.

Our laboratory is interested in the development of Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs). We have previously demonstrated that the thrombopoietin receptor, MPL, is essential for the development of these diseases via its interaction with the JAK2V617F oncogene (Blood, 2014. 124(26): p. 3956-63). This is one of three postdoctoral research associate positions as part of a CRUK Programme awarded to Dr Hitchcock, and will focus on identifying mechanisms to antagonise the thrombopoietin receptor to gain a better understanding of JAK2V617F- positive MPN development and to initiate the development of novel therapeutic interventions. This work will be in collaboration with co-Investigators Professor Jacob Piehler from Osnabruck University, Germany and Professor Steve Wedge, Northern Institute of Cancer Research, Newcastle University.

You will conduct research under the supervision of senior colleagues and contribute to the production of research and assist in the identification and development of potential areas of research and the development of proposals for independent or collaborative research projects. You will develop and initiate collaborative working internally and externally, providing guidance to other staff and students. You will write up research results and dissemination through publications, seminar and conference presentations, and public engagement and outreach activities.

You will already possess or will be awarded a relevant PhD within 3/6 months of starting the post, and have experience in molecular cell biology, cell line development, in vitro analysis of cell growth, human primary cell isolation, immunocytochemistry, microscopy, and experience in developing murine in vivo models. An understanding of membrane receptor biology and high-throughput cellular assays is desirable. You will need to be able to work independently as well as part of the programme team working on related projects. Excellent communication skills are essential, and you should be keen to develop project/team leadership skills.

This post is full time, for up to 3 years. This is a grade 6 post, with salary in the range of £31,076 – £32,004 per year.

Closing date - 05 September 2017.

Vacancy reference - 5938

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Northern England