Postdoctoral Research Scientist in Neuroscience

University of Oxford - Nuffield Department of Clinical Neurosciences (NDCN), Sleep and Circadian Neuroscience Institute (SCNi), Sir William Dunn School of Pathology and Warneford Hospital Clinical Research Facility

We are seeking to appoint a postdoctoral research scientist to work within the Sleep and Circadian Neuroscience Institute (SCNi) at the Nuffield Department of Clinical Neurosciences in the laboratory of Dr Stuart Peirson.

The clock genes cryptochrome 1 and 2 (CRY1-2) play a key role in the negative limb of the molecular circadian clock. CRYs are also expressed in the mammalian retina, and recent data from our lab has demonstrated that CRY1 and CRY2 are differentially expressed in the retina and play different roles in regulating retinal physiology. However, the functional relevance of these CRY-dependent retinal rhythms is unknown.

In addition, low-frequency magnetic fields have been shown to modulate biological responses in insects via a mechanism involving CRY in the presence of light. Whilst magnetic fields have no effect on SCN clock function, retinal CRY expression provides a mechanism by which this protein may function as a light-dependent magnetoreceptor.

You will hold a PhD or equivalent in Neuroscience or Genetics, or a relevant research area. The successful applicant will be responsible for conducting in vitro and in vivo studies on the role of CRY in the mammalian retina. Central to this will be the preparation of vectors for in vivo CRY delivery using AAV. As such, the ideal candidate would possess a strong background in molecular biology, coupled with in vivo experience. Specific in vivo training is available in post. Expertise in visual neuroscience or circadian biology would be an advantage. The postholder will also be responsible for supporting our ongoing collaborations with the Hastings lab at the Laboratory of Molecular Biology (Cambridge).

The post is full time until 31 December 2018 in the first instance. Funding is available for a starting salary at Grade 7 point 1 (£31,076 p.a.).

Only applications received before 12.00 midday on Monday 11 September 2017 will be considered.

Interviews will be held as soon as possible thereafter.

Closing Date: 11-SEP-2017 12:00

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