Postdoctoral Research Scientist: Targeting Dysregulated Translational Control in the Tumour Environment

The Beatson Institute for Cancer Research

Initial 3 year fixed term contract (with possibility of up to 2 year extension)

Profs. Jim Norman & Owen Sansom

In collaboration with Prof Martin Bushell and Dr. John Le Quesne (MRC, Leicester)

Cancer Research UK Beatson Institute in Glasgow is one of Europe's leading cancer research centres. It supports cutting edge research into the molecular mechanisms of cancer development. The Institute provides an outstanding research environment, underpinned by state-of-the-art core services and advanced technologies with special emphasis on imaging, metabolomics and in vivo models of cancer.

We are seeking an ambitious postdoctoral fellow to work on a project to investigate how the mRNA translation machinery may be targeted to treat cancer.  This project will focus on the different roles that the translational apparatus may play in the tumour and stromal compartments. In particular, this position will investigate how ribosome function in carcinoma-associated fibroblasts is attuned to manufacture large quantities of extracellular matrix and other secretory factors that generate pro-invasive and pro-metastatic tumour microenvironments. The overall research programme will focus on pancreatic and lung cancers and will be conducted in close collaboration with Prof. Martin Bushell and Dr. John Le Quesne at the MRC Toxicology Unit in Leicester.  The successful candidate will have an interest in elucidating molecular and cellular mechanisms through which the cell’s mRNA translation machinery can influence secretory processes and how this affects tumour progression and metastasis using in vivo models. 

This project will be of interest for those seeking to work on novel aspects of cell biology in the context of cancer, and who wish to undertake cross-disciplinary approaches to medical science and cancer research.  In particular we are seeking applicants who have recently completed their PhD. training and whose ambition is to obtain an independent group leader/PI position in 5-6 years’ time.

You will have successfully completed a PhD in a field relevant to mRNA biology, translational control, cell signalling and/or cell adhesion/migration. You will have published primary research papers (or have these papers in revision/in press) on relevant topics and preferably have skills in microscopy, cell and molecular biology as well as some knowledge of cancer models. 

Informal enquiries regarding this post may be made by e-mail to Prof. Jim Norman j.norman@beatson.gla.ac.uk or Prof. Owen Sansom o.sansom@beatson.gla.ac.uk

All applications must be made via our website at http://www.beatson.gla.ac.uk/careers/postdoctoral-fellows/

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