Postdoctoral Research Associate

University of Edinburgh - College of Science and Engineering - School of Biological Sciences

Are you a highly motivated and talented postdoctoral researcher interested in developing synthetic biology and genome editing approaches to address industrial challenges? Then this is the project for you.

Global spending on medicines is expected to grow to nearly $1.2 trillion by 2016 and biologics are predicted to contribute an ever-increasing proportion of this ($200-$220 billion). Biologics (large proteins such as insulin or antibodies or smaller antibody fragments) have been highly successful both as therapeutics and as diagnostics. However, they are difficult and costly to manufacture: CHO (Chinese Hamster Ovary) cells are the most widely used industrial production platform for biologics, but struggle to express some protein-based therapeutics at high quality and sustained high levels. The industry is interested in new strategies and production platforms to reduce cost.

In this project we wish to combine innovative approaches to concomitantly increase the capacity of CHO cells to express and secrete important industrially relevant biologics. There will be multiple opportunities for the post holder to interact with leading academics and industrial partners in this exciting project.

Applicants should have or shortly obtain a PhD in an appropriate discipline with research experience in at least one of the following: CHO cell biologics/protein production, synthetic biology, genome editing/engineering, mammalian cell engineering, molecular biology, molecular genetics or a related area. You must have excellent verbal and written communication skills and be able to write clearly and succinctly for publication. You must also be able to develop and apply new concepts, and have a creative approach to problem-solving. 

The successful candidate will join the lab of Prof Susan Rosser (http://rosser.bio.ed.ac.uk/) and be part of the growing PhD cohort attached to the UK Centre for Mammalian Synthetic Biology (CMSB) (http://www.synbio.ed.ac.uk/).

This post is full time and fixed term for 3 years. The post is available from October 2017.

Closing Date: Monday 2nd October 2017 at 5pm (GMT)

For further particulars and to apply for this post please click on the 'apply' button below

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