Research Fellow in Virology

University of Leeds - School of Molecular & Cellular Biology

Are you an ambitious researcher looking for your next challenge? Do you have an established background in virology or cell biology? Do you want to further your career in one of the UKs leading research intensive Universities?

Working on the project ‘A novel therapeutic use of glibenclamide to treat BK virus associated kidney disease’, you will join a thriving and multidisciplinary research group and have the opportunity to contribute to an exciting piece of work, which has the potential to transform therapy for a debilitating disease in kidney transplant patients.

BK polyomavirus-associated nephropathy (PVAN) is a cause of significant morbidity and the leading cause of graft loss in kidney transplant patients. Despite the increasing incidence of PVAN in the kidney transplant population current therapies against BK infection have limited effect or are nephrotoxic. Given the paucity of treatment options, there is a clear unmet clinical need to develop better therapies for PVAN, since any new treatment option would have the potential both to reduce patient morbidity and improve kidney transplant survival.

We recently identified host ion channels as an essential factor required for BK virus infection. Importantly, treatment of primary kidney cell cultures with the clinically available drug glibenclamide prevented BK virus infection. Glibenclamide targets host ABC transporters. Many of these form complexes with ion channel sub-units and are essential for a wide range of host processes. We will identify the composition of host channels targeted by glibenclamide in renal cells and patient tissues and characterize the stage in the BK lifecycle impaired by glibenclamide. Importantly, glibenclamide will be tested against clinical isolates of BK virus from a range of serotypes obtained from patients with PVAN. This improved understanding is expected to lead translationally into clinical studies to utilise glibenclamide for the treatment of BK nephropathy.

With the ability to manage competing demands effectively, you will be highly motivated and able to work effectively within a multidisciplinary team, which includes clinical colleagues in the kidney transplant unit at St-James’ University Hospital. You will have a PhD in virology, cell biology, molecular biology or a related discipline, or have submitted your PhD prior to the appointment start date. A strong background in primary cell culture would be an advantage.

The University of Leeds and the Faculty of Biological Sciences are committed to providing equal opportunities for all and offer a range of family friendly policies. The University is a charter member of Athena SWAN (the national body that promotes gender equality in higher education), and the Faculty of Biological Sciences gained a Bronze award in 2014 and submitted an application for a Silver award in April 2017. We are proud to be an inclusive Faculty that values all staff, and are happy to consider job share applications and requests for flexible working arrangements from our employees. Our Athena SWAN webpage provides more information. http://www.fbs.leeds.ac.uk/equality-and-diversity/athena-swan/

To explore the post further or for any queries you may have, please contact:

Dr Andrew Macdonald, Associate Professor in Virology

Tel: +44 (0)113 343 3053, email: a.macdonald@leeds.ac.uk

Contract Type: Fixed Term (3 year, due to funding)

Share this job
     
  Share by Email   Print this job   More sharing options
We value your feedback on the quality of our adverts. If you have a comment to make about the overall quality of this advert, or its categorisation then please send us your feedback
Advert information

Type / Role:

Location(s):

Northern England