Postdoctoral Research Assistant

Queen Mary University of London - Barts Cancer Institute - Centre for Tumour Biology

Applications are sought for a Postdoctoral Research Assistant to undertake genetic and phenotypic investigations into the evolution of Barrett’s oesophagus to cancer using a bioinformatic and modelling strategy. The position will be supervised by Dr Stuart McDonald (, to realise the objectives of a Cancer Research UK funded programme grant predicting risk of cancer development in patients with Barrett’s oesophagus and the candidate will work in a multidisciplinary group.

Barrett’s oesophagus is a precursor lesion of oesophageal adenocarcinoma. Barrett’s is common but conversion to cancer is rare. However ALL Barrett’s patients undergo endoscopic surveillance for cancer yet there are no prognostic biomarkers to predict cancer risk. We believe that this is because we do not understand the evolution of Barrett’s to cancer. We are seeking an experienced post doctoral scientist to investigate how the diversity of Barrett’s glands themselves evolve with the intent of developing a predictive model of cancer risk using genetic and phenotypic data. Experience in bioinformatics and/or modelling is essential in order to perform novel analysis of genomic data acquired from a cohort of patients followed over time that either have or have not progressed to cancer.  We hope to determine evolutionary patterns that can predict cancer risk. The successful candidate will be expected to help develop novel methodology that will allow clinicians to stratify patient surveillance based on cancer risk and their response to therapy.

The research will be based in the Centre for Tumour Biology, Barts Cancer Institute, within the Barts and The London School of Medicine and Dentistry, Queen Mary University of London.

Essential requirements for this post include a PhD in a relevant bioinformatics or mathematics or biological subject (with a significant component of analysing and modelling big data) and an undergraduate degree in a relevant subject. Research experience in bioinformatics or mathematics or genetics is essential. An appropriate publication record is essential. A demonstrated ability to communicate well, work within a team are also essential.

The post is full time, fixed term position for 3 years (with a further 3 years upon renewal). Starting salary will be in the range £32405-£42431 per annum inclusive of London Allowance. Benefits include 30 days annual leave, a defined benefit pension scheme and an interest free season ticket loan.

The Barts Cancer Institute requires applicants to provide all certificates at interview to confirm their qualifications (specified in the job description). Please be aware there are specific job descriptions for each post.

Candidates must be able to demonstrate their eligibility to work in the UK in accordance with the Immigration, Asylum and Nationality Act 2006. Where required this may include entry clearance or continued leave to remain under the Points Based Immigration Scheme.

Informal enquiries about this post, including arrangements to visit the Institute/Centre are encouraged and can be made to Dr Stuart McDonald Tel: 0207 882 3800 or email Website:

Details about Barts Cancer Institute can be found at

To apply, please click the 'Apply' button below.

The closing date is 30th September 2016 and the interviews are likely to be held in the week commencing 10th October 2016. It is expected the positions will commence 3rd January 2018 although there is some flexibility.

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