Project Research Scientist in Cancer Genetics

The Francis Crick Institute

Contract: Fixed-term (2 years), Full time

Short Introduction/Summary

We seek a highly motivated postdoctoral fellow to work on a collaborative project between the Cancer Systems Biology Lab at the Francis Crick Institute (Lead: Francesca Ciccarelli) and the Target Selection Team at Astra Zeneca UK (Lead: Paul Smith). The collaboration involves a multi-disciplinary efforts including cancer biology, computational genomics and chemistry. Extensive experience in molecular and cellular biology techniques and a solid knowledge of cancer genetics are required.

Project Scope/ Description

This research project aims to discover synthetic gene dependencies that can be exploited to develop innovative treatments for colorectal cancer. Dr Ciccarelli’s team has long-standing experience in identifying synthetic dependencies between genes that undergo cancer-specific inactivation and their functional compensators (D’Antonio Cell Reports 2013; Benedetti Oncotarget 2017).

Building on the synergistic collaboration between the Ciccaellli lab and the Target Selection Team at AstraZeneca, this project aims to (1) prioritise synthetic dependencies with the highest potential of being therapeutically relevant for cancer and (2) validate them with a variety of approaches in established and primary cancer cell lines. The post holder will be responsible for both these aims, namely the selection of the best candidates and their experimental validation as potential drug targets.  

The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.

The Crick was formed in 2015, and in 2016 it moved into a brand new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under a single roof in Europe.

The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; to developing emerging talent and exporting it the rest of the UK; to public engagement; and to helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.

The closing date for applications is 01 October 2017 at 23:30 pm.

Please note: all offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.

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