Research Associate

Imperial College London - Gene Therapy - National Heart and Lung Institute

Campus: Royal Brompton

We are looking for a Research Associate to provide support for the pre-clinical phase of a translational research programme aimed at assessing a lentiviral vector uniquely engineered for gene transfer to the lungs within the Gene Therapy Section at the National Heart and Lung Institute.

The research programme is led by Professors Eric Alton and Uta Griesenbach. The Gene Therapy Section is a multi-disciplinary research team and is part of the UK Gene Therapy Consortium.

In 2001, the UK Cystic Fibrosis Gene Therapy Consortium was formed to pool the expertise and resources of three major groups in the UK (Oxford and Edinburgh Universities and Imperial College), progressing from laboratory studies to the first demonstration that gene therapy can produce improvements in the lungs of CF patients in a Phase 2b clinical trial. This new project will bring together both the translational science and the teams’ expertise in evaluating new therapeutics in clinical trials for the treatment of other lung conditions. Our aim is to rapidly translate our Lentiviral gene delivery platform for a portfolio of diseases. The funds supporting this research project are provided by The Wellcome Trust.

You will develop anti-protease gene therapy for inflammatory lung diseases such as alpha 1-antitrypsin deficiency.

You will also be expected to contribute to supervision of technicians and students, and participate in teaching related activities within College as well as identifying and developing suitable techniques, and apparatus, for the collection and analysis of data.  Other duties include, but are not limited to; conduct data analysis, write reports for submission to research sponsors and direct the work of small research teams.

You should have a PhD in Molecular Biology or related discipline or equivalent research and have knowledge of gene therapy, vectorology and vector production. It is essential that the you have practical experience in a broad range of laboratory techniques such as vector production, in vitro and in vivo gene transfer, molecular biology, tissue culture and be computer literate with a good knowledge of different computer programs with experience in data presentation and statistical analyses.

The post is full-time and fixed-term for 3 years. Should you have any queries please contact:

Professor Uta Griesenbach - u.griesenbach@imperial.ac.uk

Job Reference: RB116-17

Closing date: 5 October 2017

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Our preferred method of application is online via our website http://www3.imperial.ac.uk/employment (please select “Job Search” then enter the job title or vacancy reference number into “Keywords”). Please complete and upload an application form as directed.

Alternatively, if you are unable to apply online, please email rb.recruitment@imperial.ac.uk to request an application form.

Committed to equality and valuing diversity, we are also an Athena SWAN Silver Award winner, a Stonewall Diversity Champion, a Disability Confident Employer and are working in partnership with GIRES to promote respect for trans people.

The College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published. For more information, see https://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-evaluation/

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