Postdoctoral Research Scientist in Cell Biology and Genetics using Drosophila Melanogaster and Human Cell Lines

University of Oxford - Department of Physiology, Anatomy and Genetics, Oxford

Applications are invited for a Postdoctoral Research Scientist to work with Professor Clive Wilson’s and Professor Deborah Goberdhan’s groups on an exciting BBSRC-funded research project investigating the regulated secretion of exosomes, secreted microvesicles that mediate cell-cell signalling events.

The postholder will use a unique Drosophila in vivo system developed by the collaborating groups as well as human cancer cell-based assays. There are close collaborations with several clinicians in Oxford, including Professor Adrian Harris (Weatherall Institute of Molecular Medicine), Professor Freddie Hamdy (Nuffield Department of Surgical Sciences) and other colleagues in the CRUK Oxford Centre, which will allow findings from the project to be translated to patient studies.

We have already employed the fly model to identify novel and evolutionarily conserved subcellular sources of different exosome subtypes. You will use genetic and cellular approaches to investigate how secretion of these different exosomes is controlled in flies and then in cancer cell lines. Inducible genetic knockdown and newly developed super-resolution (3D-SIM) and real-time microscopy techniques will be used in flies to test candidate regulatory genes and their functions, while several exosome isolation strategies and functional assays will be employed in cell culture.

You must have, or be near completion of, a PhD in a relevant area of cell or developmental biology. Experience is required in Drosophila genetics, as well as molecular genetics and/or cell biology.  Specialist knowledge relating to the project should be demonstrated. Previous experience in several approaches that will be employed is desirable, e.g. fly molecular genetics, advanced fluorescence microscopy. This is an excellent opportunity to develop skills in both Drosophila and human cell biology, while working in the exciting and expanding area of exosome signalling.

The post will be based in the in the Department of Physiology, Anatomy and Genetics, Le Gros Clark Building, South Parks Road, Oxford OX1 3QX.

The post is funded for up to 3 years.

The closing date for applications is 12.00 noon on Monday 9 October 2017. Interviews are likely to be held on Thursday 19 October 2017.

Please note that the University of Oxford's retirement policy is changing. With effect from October 1 2017, all employees at Grade 8 and above will have a retirement age of 68, and all employees at Grades 6 and 7 will no longer have a set retirement age. Further details are available at: 

Closing Date: 09-OCT-2017 12:00

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