Research Associate - Protein Aggregates (Fixed Term)

University of Cambridge - Department of Chemistry

Fixed-term: The funds for this post are available for 2 years in the first instance.

Applications are invited for a Post-Doctoral Research Associate in the Centre for Misfolding Diseases who will use interdisciplinary approaches to studying mechanistic, structural and toxic features of protein aggregates associated with neurodegenerative disorders, in particularly, Parkinson's Disease.

The successful candidate will use a variety of biophysical techniques to expand on a recently developed, three-pronged strategy to study the kinetics of ¿-synuclein amyloid formation and to look at strategies which can inhibit protein aggregation, with a focus on single-point mutations associated with familial Parkinson's disease. The structural attributes of different aggregate species will be characterised with a number of biophysical techniques (i.e. X-ray diffraction, AFM, FTIR, CD) and investigations as to how these aggregates induce permeability of lipid bilayers will be explored using newly developed single molecule techniques.

Applicants should have (or be about to receive) a Ph.D. in Chemistry with a background in protein misfolding diseases. They will have extensive experience analysing the kinetics of amyloid aggregation and detailed knowledge of biophysical techniques such as plate-reader based aggregation assays, X-ray diffraction, AFM, FTIR and CD spectroscopies are essential. They will have experience with recombinant protein expression in E. coli and purification techniques (ion exchange and SEC chromatography), and experience with total internal reflection microscopy is desirable. The candidate will have excellent communication skills and they will have the ability to work effectively as part of a multi-disciplinary team.

To apply online for this vacancy and to view further information about the role, please visit:

www.jobs.cam.ac.uk/job/14937. This will take you to the role on the University’s Job Opportunities pages. There you will need to click on the 'Apply online' button and register an account with the University's Web Recruitment System (if you have not already) and log in before completing the online application form.

Please ensure that you upload your Curriculum Vitae (CV), a covering letter and publications list in the upload section of the online application. If you upload any additional documents that have not been requested, we will not be able to consider these as part of your application.

For queries regarding applying online for this post, please contact Mrs. Echo Wu-Williamson (jw825@cam.ac.uk)

For more information about the post please contact Dr. Janet Kumita (jrk38@cam.ac.uk)

Please quote reference MA13268 on your application and in any correspondence about this vacancy.

The Department holds an Athena SWAN silver award for women in Science, Technology, Engineering, Mathematics, and Medicine.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

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South East England