Senior/Laboratory Research Scientist

The Francis Crick Institute

Contract: Fixed-term (6 months)/Full time

Short Introduction/Summary

We seek a highly motivated scientist, with a strong interest in immunology, cancer and mouse genetics. Scientific research activity will involve the development and running of own research in direct contact with Dr Dinis Calado and the participation in experiments of other laboratory members.

A major interest of the Immunity and Cancer Lab is to understand how healthy cells become cancerous. To address this question the laboratory currently focuses on the study of B cells that are an essential cellular component of the immune system.

Project Scope/ Description

The Immunity and Cancer Laboratory uses an integrative approach to immunology and cancer biology. Projects available in the lab include:

(i) Identify and study subpopulations within healthy B cells at a high risk of cellular transformation i.e. “cells of origin in cancer”,

(ii) Investigate the causative mutations in B cell derived malignancies,

(iii) Assess the processes of evasion of cancer cells from immune control by determining the nature of the interplay between a developing B cell cancer and cells of the immune system.

To perform these studies the lab takes advantage of inter-species comparisons. The lab has cutting-edge genetic techniques in place to address these questions in vivo in the mouse. The validation of the findings in these systems are obtained through the study of human samples of B cell derived cancers.

The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.

The Crick was formed in 2015, and in 2016 it moved into a brand new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under a single roof in Europe.

The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; to developing emerging talent and exporting it the rest of the UK; to public engagement; and to helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.

The closing date for applications is 05 October 2017 at 23:30 pm.

Please note: all offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.

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