Enzymologist (Grade 7)

University of Dundee - Drug Discovery Unit

The Drug Discovery Unit (DDU) (see http://www.drugdiscovery.dundee.ac.uk) is a fully integrated drug discovery operation based within a world class Life Sciences research environment. Its remit is to complement BioPharma activities by tackling both neglected diseases (trypanosomiasis, leishmaniasis and malaria) and early stage small molecule validation of novel targets & mechanisms across a range of potential therapeutics areas. The DDU works to Biotech style philosophy and standards incorporating, dynamic, goal driven project management based on Target Product Profiles and Compound Selection Criteria. The project goals are therapeutic area dependent but range from quality leads demonstrating disease model proof of concept, through to pre-clinical candidates.

We are currently looking for a highly motivated enzymologist to be part of a BioPharma experienced, multi-disciplinary team in the DDU. The post is available immediately. Salary will depend on experience, but will be up to £38,883. This is a unique opportunity to gain experience in industry-style drug discovery within an academic setting.

Main Responsibilities:

  • Development of new approaches to define mechanism of action of enzyme inhibitors.
  • Development of diversity screening assay for drug discovery projects.
  • Screening of small-molecule compounds libraries in enzyme assays.
  • Support for other internal and external enzyme projects.
  • Management and development of biochemical infrastructure (in conjunction with suppliers and lab managers).
  • Development of innovative approaches for enzymology screening.

Requirements:

Essential:

  • PhD/post-doctoral or equivalent industry experience in enzymology.
  • First-hand experience with approaches for defining mechanism of action of small molecule enzyme modulators.
  • Expertise in enzyme experimental design.
  • Expertise in biochemistry and pharmacology.
  • Ability to work in teams, and to work to timelines and deliver milestones.
  • Flexible approach to projects; project priorities may change based on overall portfolio needs and strategy.

Desirable:

  • Knowledge of the drug discovery process, with a particular focus on the hit-discovery stage.
  • Experience with curve-fitting, data handling and analysis.
  • Expertise with lab-automation.
  • Experience in industry-standard recording keeping.
  • Understanding of statistics relevant to high-throughput screening.
  • Track record of presenting and communicating research results.

Dundee, set on the east-coast of Scotland, lies in an area of outstanding natural beauty, including large sandy beaches and challenging hills. Rainfall charts show this is one of the sunniest and driest places in the UK.

For informal discussion about the post please contact Dr David Gray, tel: (01382) 386247 or e-mail: d.w.gray@dundee.ac.uk.

Additional Information
The University of Dundee is a diverse community and is committed to equality of opportunity for all by providing a supportive, flexible and inclusive working environment. We have family friendly policies (including flexible working and childcare vouchers), staff groups for LGBT and BME; and prayer room facilities.

The University of Dundee has received the Athena SWAN Bronze Award (Athena Swan) which recognises the promotion of gender equality and has made further commitment to advancing inclusive culture which supports and encourages all under-represented groups.

The University of Dundee is a Scottish Registered Charity, No. SC015096.

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Scotland