PhD Studentship: Single Molecule Imaging of Protein Aggregates in Cells

University of Cambridge - Department of Chemistry

Applications are invited for a PhD studentship in the group led by Professor David Klenerman, on a multi-disciplinary project which exploits novel single molecule  fluorescence methods developed in the Klenerman group to image protein aggregates on or in neuronal cells and characterise their structure and properties (see Angew.Chem.Int. (2017) 56, 7750 and ACS Chemical Neuroscience (2016) 7, 399).  The aim is to understand why aggregates accumulate with time in cells and their mechanism of cytotoxicity.  Both are fundamental processes that occur in neurodegenerative diseases such as Alzheimer's and Parkinson's disease.  The imaging is based on single molecule fluorescence using home-built total internal reflection fluorescence microscopes that allow us to determine the location of individual aggregates in the cell and also characterise their size and structure.  This project will suit a student trained in chemistry, physics or biophysics who wants to apply physical methods to an important biomedical problem.  No prior experience in biology is required.

Applicants must have (or expect to obtain) at least the equivalent of a UK upper second class honours degree (and preferably a Masters) in chemistry, physics, biophysics or other relevant discipline.

The studentship provides a maintenance grant and tuition fees at the UK/EU rate. Non-EU nationals will be considered only if they can cover the differential for overseas tuition fees.

Applications should include a cover letter, a CV, detailed academic transcripts and the contact details for at least two academic referees, and should be emailed to:  Professor David Klenerman (dk10012@cam.ac.uk) to whom any informal enquiries can be addressed.

If you wish to be considered for any other available studentships in the Chemistry Department, you must also apply online via the University Applicant Portal and complete the Chemistry Department Application form (further information at http://www.ch.cam.ac.uk/pgapp). Please note that there is an application fee.

Information about research in the Department of Chemistry is given at: http://www.ch.cam.ac.uk

Please quote reference MA13402 on your application and in any correspondence about this vacancy.

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Type / Role:

PhD

Location(s):

South East England