Postdoctoral Researcher

John Innes Centre, Norwich - Bomblies laboratory

Applications are invited for a Postdoctoral Researcher to join the Bomblies laboratory at the John Innes Centre. The Bomblies laboratory works on understanding the mechanistic basis of the adaptive evolution of meiosis in response to both genome and habitat change. The main focus is currently on understanding the genetic basis of adaptation of polyploid lineages to their genome duplicated state, which seems to primarily involve a reduction in crossover rates. We are building on our prior discovery of several meiotic genes under selection in an autopolyploid lineage of Arabidopsis arenosa. The goal of the laboratory is to use a variety of approaches including cytology, genetics, and structural/biochemical/molecular approaches to understand how evolution solved the vexing problem of sorting chromosomes after whole genome duplication. This seems to involve a restructuring of core meiotic processes with the end result of reducing crossover rates, more distal localization of crossovers, and preventing formation of multivalent chromosome associations. Our prior analyses of genome evolution suggest a short list of cohesin, axis and synaptonemal complex proteins are key to the modified meiosis of polyploids. Our overall goal is to understand the causes and consequences of the evolutionary changes in these core proteins.

This ERC-funded position will investigate the functional divergence of the synaptonemal complex protein ZYP1 in a polyploid lineage of Arabidopsis arenosa. The successful applicant will have a PhD (full award or expected within 6 months) or equivalent in Biology, Genetics, or a related discipline. Experience in cytology, preferably on plants, is essential, as is experience with genetics and ideally also molecular biology (e.g. cloning, transgenesis). The successful candidate will need to integrate well into the group to work with other lab members who investigate interacting proteins. The post holder will work towards undertaking largely independent research to understand how and why the synaptonemal complex proteins evolved the way they did in the tetraploid A. arenosa lineage.

Salary on appointment will be within the range £31,250 to £38,100 per annum depending on qualifications and experience. This post is for a contract of 24 months.

For further information and details of how to apply, please visit our web site or contact the Human Resources team on 01603 450462 or quoting reference 1003342.

As a Disability Confident employer, we guarantee to offer an interview to all disabled applicants who meet the essential criteria for this vacancy. The John Innes Centre is also proud to hold a Silver Award from Athena SWAN and is a member of Stonewall’s Diversity Champions programme.

The John Innes Centre is a registered charity (No. 223852) grant-aided by the Biotechnology and Biological Sciences Research Council and is an Equal Opportunities Employer.

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