Research Associate

Imperial College London - Section of Virology, Division of Infectious Diseases/Department of Medicine/Faculty of Medicine

Campus: St Mary’s

An exciting opportunity has arisen for a postdoctoral Research Associate in the Section of Virology within the Division of Infectious Diseases, Department of Medicine at Imperial College London.

You will join a productive group headed by Professor CRM Bangham, carrying out research on the cellular immune response, virology and cell biology of infection with the human T-cell leukaemia virus type, HTLV-1. 

The new project focuses on viral oncogenesis and is funded by a Project Grant from the Medical Research Council, in a collaboration with Professor M. Katan, University College London.  We will investigate the acquisition and impact of mutations in the phospholipase C-gamma 1 (PLCg1) gene in individuals infected with HTLV-1: these mutations can lead to malignant transformation of the infected T-cell, resulting in the devastating condition called adult T-cell leukaemia/lymphoma (ATL). Individuals with expertise in molecular techniques and T-cell biology are particularly encouraged to apply.

You will learn and carry out targeted gene editing of primary human T-lymphocyte clones by transfection of CRISPR/Cas9 ribonucleoprotein, using a protocol that is in use in this laboratory.  You will investigate the impact of these mutations on the growth, gene expression and function of T lymphocytes in vitro.

You must have a PhD or equivalent in virology, immunology or a closely related discipline. Successful research experience in HTLV-1 infection or a similar field, including publications in reputable journals, is essential.

The post is full time and is available for two years, to start as soon as possible. The contract is subject to the normal terms and conditions of employment in Imperial College. For details about the project or the role, please contact Professor Charles Bangham – c.bangham@imperial.ac.uk. Should you have any queries about administrative details, please contact: Ms Michelle Kiely – m.kiely@imperial.ac.uk

Our preferred method of application is online via our website http://www3.imperial.ac.uk/employment (please select “Job Search” then enter the job title or vacancy reference number HM2017185 into “Keywords”). Please complete and upload an application form as directed.

Should you have any queries relating to submitting your application form please contact: Emma Jones – e.jones@imperial.ac.uk

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