Research Associate, In vitro Molecular Neurodegeneration – UK Dementia Research Institute

Imperial College London - Medicine, Brain Sciences, Medicine

Campus: Hammersmith (White City from 2019)

The UK Dementia Research Institute (UK DRI) at Imperial has been established to address a medical research area of highest importance and future impact, as one of six new national centres of excellence embedded in major UK universities that together, are intended to transform the diagnosis, treatment and care of people with dementias. MRC and charity partners Alzheimer's Society and Alzheimer’s Research UK have invested £250m in fulfilment of the ambition identified in the Prime Minister's 2020 Challenge on Dementia.

The UK DRI at Imperial is seeking an outstanding post-doctoral researcher interested in taking on a challenging role with considerable scope for independent scientific achievement and personal growth. The post-holder will be a key member of the research staff in the group of the Centre Head and Institute Associate Director, Professor Paul Matthews.

The work will focus on relating changes found in human neuropathological samples with those in relevant in vitro cell and, through collaboration with colleagues in the laboratory, preclinical in vivo models. The studies will initially employ immunofluorescence, proteomics and transcriptomic methods, including recently developed nucSeq approaches. Assisted by collaborations with bioinformaticians, analyses will be conducted to characterise patterns of gene and protein expression and their regulation and how signals between glial and neuronal cells may alter these in disease.

The successful candidate will be expected to help to define specific research programmes within this remit and undertake them in conjunction with colleagues in often multi-disciplinary teams. Considerable independence will be expected, with anticipation for a growing role in leadership of the research.  In addition, he/she will be expected to submit publications to refereed journals and to join in attracting external research funding.

There will be opportunities for supervision of students. Experiences in other teaching roles, including lecturing, will be enabled as part of the broad range of career development opportunities that Imperial College makes available to its post-doctoral research staff.

The contract is fixed term to 31 August 2019 in the first instance, with a possibility of extension to August 2022.

For informal inquiries or questions about the role, please contact Prof Paul Matthews directly at

Imperial Expectations guide the behaviour of all our staff.

Should you have any queries about applying for the role, please contact:

Michelle Buckman:

Committed to equality and valuing diversity, we are also an Athena SWAN Silver Award winner, a Stonewall Diversity Champion, a Disability Confident Employer and are working in partnership with GIRES to promote respect for trans people.

The College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published. For more information, see

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